Assessment of HDL functionality for the prevention of acute coronary syndrome in patients with coronary artery disease
Description: Cholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). We evaluated the clinical implication of HDL Cholesterol uptake capacity (CUC) in patients treated with coronary artery disease. CUC has shown to be correlated with plaque vulnerability and in-stent neoatherosclerosis assessed by optical coherence tomography. This study demonstrated intensive lipid-lowering therapy using statin and eicosapentaenoic acid has enabled to stabilize vulnerable plaques and suppress the progression of neoatherosclerosis.
Amount: ¥2,860,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Toshiro Shinke
Institution: Showa University
Funded outputs count: 7
Funder award ID: 17K09553
OpenAlex ID: G5279929196