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A strategy for the rejuvenation of older donor kidney focusing the research for development, stem cell biology and kidney-bone marrow axis: The establishment of international joint research network

Description: 骨髄老化により引き起こされる腎臓老化・病態メカニズムの解明を目的とし、国際ネットワークを構築する。幹細胞老化・ミトコンドリア機能変化・糖鎖修飾異常・発生に関わる転写因子に着目したマウスモデルによる多臓器間老化メカニズムの解明と、その成果を元に、腎臓の老化・若返りを試みる検証システムの構築を遂行する。腎臓を中心とした複数臓器の老化メカニズムの解明及び高齢者に対する革新的腎臓病治療へと繋げる。
Amount: ¥18,330,000
Funding type: research
Funder scheme: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Start date: 2019-10-07
End date: 2022-03-31
Investigator: Joichi Usui
Institution: University of Tsukuba
Funded outputs count: 36
Funder award ID: 19KK0216
OpenAlex ID: G5283841219
2022 · Yumi Ohori-Morita, Kunimichi Niibe, et al. · Stem Cells Translational Medicine · 35
2021 · Kunio Kawanishi, Joanna K. Coker, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 39
2021 · Kazuhiro Sudo, Satoshi Yamazaki, et al. · Stem Cell Research · 14
2021 · Yo Mabuchi, Chikako Okawara, et al. · Frontiers in Cell and Developmental Biology · 58
2021 · Joichi Usui, Kunihiro Yamagata, et al. · Annals of Transplantation · 1
2021 · Morio Yamazaki, Kotaro Sugimoto, et al. · Biomedicines · 4
2020 · Kunio Kawanishi, Sudeshna Saha, et al. · Journal of Clinical Investigation · 25
2020 · Seiko Harada, Yo Mabuchi, et al. · Stem Cells · 45
2020 · Heinz Läubli, Kunio Kawanishi, et al. · FEBS Journal · 52
2020 · Wakako Kuribayashi, Motohiko Oshima, et al. · The Journal of Experimental Medicine · 110
2020 · Satotaka Omori, Teh-Wei Wang, et al. · Cell Metabolism · 194
2020 · Kiyoko Izawa, Satoshi Yamazaki, et al. · Experimental Hematology · 8
2020 · Joichi Usui, Misa Yaguchi, et al. · Scientific Reports · 10
2020 · Reina Takeda, Shuhei Asada, et al. · Blood · 17
2020 · Kazuyuki Noguchi, Junji Ishida, et al. · Proceedings of the National Academy of Sciences · 22
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