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Contextual and Health Behavior Effects on Epigenetic Aging Among African Americans

Description: PROJECT NARRATIVE As the public impact of age-related diseases has grown over time, it has become apparent that improving the quality of longer lives requires further exploration of the causes of accelerated epigenetic aging (epi-A), which forecasts heightened risk for all-cause morbidity and mortality. This proposal seeks funding to conduct new assays on existing blood samples from members of the Family and Community Health Study (FACHS), and to collect another wave of blood from these individuals, in order to assess the impact of various stressors and supports on epi-A (at age 28) and changes in epi-A from age 28 to age 33.
Funding type: research
Funder scheme: R01
Start date: 2018-08-02
End date: 2024-07-31
Investigator: STEVEN R BEACH
Institution: UNIVERSITY OF CONNECTICUT STORRS
Funded outputs count: 52
Funder award ID: R01CA220254
OpenAlex ID: G5262828799
Two Separable Aging Domains in Blood DNA Methylation Scores Developed for Cancer Research: Mitotic Replication and Early-Life Systemic Dysregulation
2026 · Katelyn N. Austin, Man-Kit Lei · Genes
Associations of Racial Discrimination with Resting-state Network Topology: A Mechanism for Post-traumatic Sensory Disruptions
2026 · Aziz Elbasheir, Leland Fleming, et al. · Research Square
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Childhood exposure to danger increases Black youths’ alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis
2025 · Steven R.H. Beach, Sierra E. Carter, et al. · Development and Psychopathology · 2
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A critical awareness approach to cluster hiring for academic inclusion
2025 · Sierra Carter, Emmanuella Asabor, et al. · Journal of the National Medical Association · 3
Objective Assessments of Smoking and Drinking Outperform Clinical Phenotypes in Predicting Variance in Epigenetic Aging
2024 · Robert Philibert, Man-Kit Lei, et al. · Genes · 6
Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women
2024 · Aziz Elbasheir, Seyma Katrinli, et al. · JAMA Network Open · 36
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Perceptions of psychedelic-assisted therapy among Black Americans
2023 · Sierra Carter, Grace Packard, et al. · Journal of Mood and Anxiety Disorders · 19
Epigenetic biomarkers for smoking cessation
2023 · Fang Fang, Allan M. Andersen, et al. · Addiction Neuroscience · 29
Association of racial discrimination in health care settings and use of electronic cigarettes to quit smoking among Black adults
2023 · Asti B. Jackson, Frederick X. Gibbons, et al. · Journal of Substance Use and Addiction Treatment · 2
Racial discrimination and the weathering of nonmarital relationships
2022 · Ashley B. Barr, Ronald L. Simons, et al. · Journal of Marriage and the Family · 7
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Specifying the psychosocial pathways whereby child and adolescent adversity shape adult health outcomes
2022 · Man-Kit Lei, Mark T. Berg, et al. · Psychological Medicine · 10
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Epigenetic and Proteomic Biomarkers of Elevated Alcohol Use Predict Epigenetic Aging and Cell-Type variation Better Than Self-Report
2022 · Steven R. H. Beach, Mei Ling Ong, et al. · Genes · 12
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Do Loneliness and Per Capita Income Combine to Increase the Pace of Biological Aging for Black Adults across Late Middle Age?
2022 · Steven R. H. Beach, Eric T. Klopack, et al. · International Journal of Environmental Research and Public Health · 17
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Association of Non-Cigarette Tobacco Advertisements and Racial Discrimination With Non-Cigarette Tobacco Product Use Among Black Adults
2022 · Asti Jackson, Mary E Fleischli, et al. · Nicotine & Tobacco Research · 10
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School Disengagement Predicts Accelerated Aging among Black American Youth: Mediation by Psychological Maladjustment and Moderation by Supportive Parenting
2022 · Mei Ling Ong, Eric T. Klopack, et al. · International Journal of Environmental Research and Public Health
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Racial discrimination associates with lower cingulate cortex thickness in trauma-exposed black women
2022 · Negar Fani, Leyla Eghbalzad, et al. · Neuropsychopharmacology · 21
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Racial discrimination predicts depressive symptoms throughout adolescence among Black youth.
2022 · Justin A. Lavner, Mei Ling Ong, et al. · Developmental Psychology · 21
Childhood adversity and adult health: A dyadic analysis of Black American couples.
2022 · Yue Zhang, Man-Kit Lei, et al. · Health Psychology · 3
Approaching Mental Health Equity in Neuroscience for Black Women Across the Lifespan: Biological Embedding of Racism From Black Feminist Conceptual Frameworks
2022 · Sierra Carter, Yara Mekawi, et al. · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · 21
Incarceration exposure and epigenetic aging in neighborhood context
2022 · Mark T. Berg, Ethan M. Rogers, et al. · Social Science & Medicine · 22
Digital methylation assessments of alcohol and cigarette consumption account for common variance in accelerated epigenetic ageing
2022 · Man-Kit Lei, Frederick X. Gibbons, et al. · Epigenetics · 17
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Racial centrality mediates the association between adolescent racial discrimination and adult cigarette smoking outcomes among Black Americans
2022 · Angela M. Haeny, Frederick X. Gibbons, et al. · Social Science & Medicine · 16
It’s about racism, not race: a call to purge oppressive practices from neuropsychiatry and scientific discovery
2022 · Sierra E. Carter, Yara Mekawi, et al. · Neuropsychopharmacology · 15
African Americans’ relationship quality and depressive symptoms: A longitudinal investigation of the Marital Discord Model.
2022 · Allen W. Barton, Justin A. Lavner, et al. · Journal of Family Psychology · 15
Childhood adversity predicts black young adults’ DNA methylation-based accelerated aging: A dual pathway model
2021 · Steven R. H. Beach, Frederick X. Gibbons, et al. · Development and Psychopathology · 18
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