Prevention of schizophrenia based on Keap1-Nrf2 system
Description: A number of epidemiological studies suggest that maternal immune activation can increase the risk of autism spectrum disorder and schizophrenia in offspring. In this study, we reported that dietary intake of Nrf2 activator glucoraphanin during pregnancy and lactation can prevent the onset of behavioral abnormalities in offspring. Furthermore, We found that maternal exposure of glyphosate can cause behavioral abnormalities in offspring of mouse, and that administration of soluble epoxide hydrolase inhibitor TPPU could prevented the onset of behavioral abnormalities in offspring. In this study, we proposed that maternal nutrition plays an important role in the mental health of offspring.
Amount: ¥15,860,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Kenji Hashimoto
Institution: Chiba University
Funded outputs count: 19
Funder award ID: 17H04243
OpenAlex ID: G5343577610