Award

Involvement of SASP in bone microenvironment

Description: The purpose of this study was to elucidate the effects of aging on osteoclast precursor cell proliferation, differentiation and SASP. It is considered that senescent osteoclast progenitor cells have reduced osteoclast differentiation potential due to decreased expression of RANK. In addition, the expression of SASP factors (iNOS, TGF-β1, HIF) was increased in senescent osteoclast progenitor cells. It is thought that it may be associated with inflammatory bone diseases such as rheumatoid arthritis due to increased production of inflammatory cytokines.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,160,000

Funding type: fellowship

Funder scheme: Grant-in-Aid for Early-Career Scientists

Start date: 2018-04-01

End date: 2020-03-31

Investigator: Joji Tamaoka

Institution: Hyogo Medical University

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences