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Delineating Molecular Mechanisms Underlying Liver Progenitor Cell-Driven Liver Regeneration

Description: Narrative Liver transplantation is the only effective treatment for patients with end-stage liver diseases; however, the shortage of donor livers makes this therapy very limited. If innate liver regeneration can be augmented in the patients, it will mitigate severe liver diseases and permit the patients to live longer. Our studies will delineate the molecular mechanisms underlying liver progenitor cell-driven liver regeneration and suggest EGFR inhibitors as promising pro-regenerative agents to augment liver regeneration in patients with chronic liver diseases.
Funding type: research
Funder scheme: R01
Start date: 2018-05-15
End date: 2022-04-30
Investigator: SATDARSHAN SINGH MONGA
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Subfield: Hepatology
Field: Medicine
Funded outputs count: 30
Funder award ID: R01DK116993
OpenAlex ID: G1043965018
PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish
2023 · Minwook Kim, Juhoon So, et al. · Scientific Reports · 9
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Wnt-β-catenin in hepatobiliary homeostasis, injury, and repair
2023 · Kari Nejak-Bowen, Satdarshan P. Monga · Hepatology · 30
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Hepatocyte-to-cholangiocyte conversion occurs through transdifferentiation independently of proliferation in zebrafish
2023 · Seung-Hoon Lee, Juhoon So, et al. · Hepatology · 14
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Ductular Reaction and Liver Regeneration: Fulfilling the Prophecy of Prometheus!
2022 · Satdarshan P. Monga, Kari Nejak-Bowen · Cellular and Molecular Gastroenterology and Hepatology · 14
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Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b
2022 · Shikai Hu, Silvia Liu, et al. · Cell Reports Medicine · 118
Hepatocyte β‐catenin loss is compensated by Insulin‐mTORC1 activation to promote liver regeneration
2022 · Shikai Hu, Catherine Cao, et al. · Hepatology · 11
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NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma
2022 · Shikai Hu, Laura Molina, et al. · Gastroenterology · 104
Therapeutic implication of SOX9 and YAP1 co‐repression in advanced intrahepatic cholangiocarcinoma
2022 · Shikai Hu, Laura Molina, et al. · The FASEB Journal · 1
Role of YAP1 Signaling in Biliary Development, Repair, and Disease
2022 · Laura Molina, Kari Nejak-Bowen, et al. · Seminars in Liver Disease · 23
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β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction
2021 · Shikai Hu, Jacquelyn O Russell, et al. · eLife · 24
Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors
2021 · Laura M. Molina, Junjie Zhu, et al. · Cell Reports · 36
β-Catenin Activation in Hepatocellular Cancer: Implications in Biology and Therapy
2021 · Yekaterina Krutsenko, Aatur D. Singhi, et al. · Cancers · 35
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Dual β-Catenin and γ-Catenin Loss in Hepatocytes Impacts Their Polarity through Altered Transforming Growth Factor-β and Hepatocyte Nuclear Factor 4α Signaling
2021 · Tirthadipa Pradhan-Sundd, Silvia Liu, et al. · American Journal Of Pathology · 6
Wnt/-Catenin Signaling and Liver Regeneration: Circuit, Biology, and Opportunities
2021 · Shikai Hu, Satdarshan P. Monga · Gene Expression · 44
Farnesoid X Receptor Activation Impairs Liver Progenitor Cell–Mediated Liver Regeneration via the PTEN‐PI3K‐AKT‐mTOR Axis in Zebrafish
2020 · Kyounghwa Jung, Minwook Kim, et al. · Hepatology · 77
NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocyte reprogramming into intrahepatic cholangiocarcinoma
2020 · Shikai Hu, Laura Molina, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Liver progenitor cell-driven liver regeneration
2020 · Juhoon So, Angie Kim, et al. · Experimental & Molecular Medicine · 111
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Attenuating the Epidermal Growth Factor Receptor–Extracellular Signal‐Regulated Kinase–Sex‐Determining Region Y‐Box 9 Axis Promotes Liver Progenitor Cell‐Mediated Liver Regeneration in Zebrafish
2020 · Juhoon So, Minwook Kim, et al. · Hepatology · 46
Impaired Bile Secretion Promotes Hepatobiliary Injury in Sickle Cell Disease
2020 · Ravi Vats, Silvia Liu, et al. · Hepatology · 19
Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns
2019 · Sungjin Ko, Jacquelyn O. Russell, et al. · Annual Review of Pathology Mechanisms of Disease · 165
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Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
2019 · Josepmaria Argemi, Maria U. Latasa, et al. · Nature Communications · 203
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mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development
2019 · Laura Molina, Hong Yang, et al. · Oncotarget · 20
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2019 · Oncotarget
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Axis inhibition protein 1 (Axin1) Deletion–Induced Hepatocarcinogenesis Requires Intact β‐Catenin but Not Notch Cascade in Mice
2019 · Yu Qiao, Jingxiao Wang, et al. · Hepatology · 55
Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations
2019 · Adeola O. Adebayo Michael, Sungjin Ko, et al. · Cell Metabolism · 155
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