A novel mechanism to regulate chronic inflammation through metabolic remodeling in obesity and senescence
Description: It is well established that the chronic inflammation is implicated in many diseases such as metabolic syndrome and cancer. However, the precise mechanism of the chronic inflammation has not been clarified yet. We have found that the chronic inflammation signaling cascade is involved in the development of type I diabetes and the accelerated aging in mouse models. Furthermore, we have demonstrated that the senescence of cells results in the metabolic remodeling which can induce the epigenetic modifications of proinflammatory cytokine genes and thus, can affect the senescence-associated secretory phenotype.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Masato OGATA
Institution: Mie University
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 6
Funder award ID: 17K08879
OpenAlex ID: G5401425697