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Mechanism of Islet Amyloid Formation

Funding type: research
Funder scheme: R01
Start date: 1997-09-15
End date: 2002-07-31
Investigator: STEVEN E KAHN
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 22
Funder award ID: R01DK050703
OpenAlex ID: G1792659609
2015 Yutaka Seino Distinguished Leadership Award Lecture: The Japanese American Community Diabetes Study and the ‘canary in the coal mine’
2016 · Wilfred Y Fujimoto · Journal of Diabetes Investigation · 13
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Optimum BMI Cut Points to Screen Asian Americans for Type 2 Diabetes
2015 · Maria Rosario G. Araneta, Alka M. Kanaya, et al. · Diabetes Care · 144
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Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
2005 · R. L. Hull, K. Kodama, et al. · Diabetologia · 150
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Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice
2005 · Rebecca L. Hull, Melissah R. Watts, et al. · American Journal of Physiology-Endocrinology and Metabolism · 12
Islet Amyloid: A Critical Entity in the Pathogenesis of Type 2 Diabetes
2004 · Rebecca L. Hull, Gunilla T. Westermark, et al. · The Journal of Clinical Endocrinology & Metabolism · 583
Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide
2004 · Sofianos Andrikopoulos, Rebecca L. Hull, et al. · American Journal of Physiology-Endocrinology and Metabolism · 5
Proteoglycans synthesized and secreted by pancreatic islet β-cells bind amylin
2003 · Susan Potter-Perigo, Rebecca L. Hull, et al. · Archives of Biochemistry and Biophysics · 42
Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid
2003 · Rebecca L. Hull, Sofianos Andrikopoulos, et al. · Diabetes · 110
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The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice
2003 · J. Vidal, C. Bruce Verchere, et al. · Diabetologia · 30
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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
2003 · S. E. Kahn · Diabetologia · 2,165
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Insulin and Amylin Release Are Both Diminished in First-Degree Relatives of Subjects With Type 2 Diabetes
2002 · Negar G. Knowles, Melinda A. Landchild, et al. · Diabetes Care · 51
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Islet Amyloid Develops Diffusely Throughout the Pancreas Before Becoming Severe and Replacing Endocrine Cells
2001 · Feng Wang, Rebecca L. Hull, et al. · Diabetes · 77
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Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes
2001 · Philippe A. Halban, Steven E. Kahn, et al. · Diabetes · 103
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The Importance of β-Cell Failure in the Development and Progression of Type 2 Diabetes
2001 · Steven E. Kahn · The Journal of Clinical Endocrinology & Metabolism · 660
beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.
2001 · D Porte, S E Kahn · Diabetes · 332
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beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
2000 · S Andrikopoulos, C B Verchere, et al. · Diabetes · 44
Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes
2000 · S. E. Kahn, S. Andrikopoulos, et al. · Diabetologia · 35
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The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells.
2000 · C B Verchere, D A D'Alessio, et al. · Diabetes · 26
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The importance of the β-cell in the pathogenesis of type 2 diabetes mellitus
2000 · Steven E Kahn · The American Journal of Medicine · 242
Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid.
1999 · S Andrikopoulos, C B Verchere, et al. · Diabetes · 15
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
1999 · S E Kahn, S Andrikopoulos, et al. · Diabetes · 489
Human aging is associated with parallel reductions in insulin and amylin release
1998 · Cynthia J. Dechenes, C. Bruce Verchere, et al. · American Journal of Physiology-Endocrinology and Metabolism · 55
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