Investigating the drugs to repair injured alveolar epithelial cells using type 2 alveolar epithelial progenitor cells with ABCA3 mutations
Description: Patients with homozygous or compound heterozygous mutations in ABCA3 gene cause severe lung diseases in infants and children. We isolated an alveolar epithelial progenitor cells (AEPCs) from human lungs. In the present study, we isolated AEPCs from 2 patients without ABCA3 mutations and from 2 patients with different ABCA3 mutations and analyzed the differentially expressed genes of the two groups.We evaluated the differentially expressed genes of AT2 derived from ABCA3-wt- and ABCA3-mt-AEPCs. Changes of cell polarity and epithelial barrier function, development associated genes in AT2 with ABCA3 mutation might be involved in the disease development.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Chiharu Ota
Institution: Tohoku University
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 8
Funder award ID: 16K10056
OpenAlex ID: G5439408319