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Enhancing the Calerie Network to Advance Aging Biology

Description: PROJECT NARRATIVE In a previously performed study, healthy persons were randomly assigned to two years of reducing calorie intake or continuing eating as usual. Results showed the low calorie group had superior benefits in multiple areas of aging-related health. Samples and data from this project remain available for additional studies to better understand calorie reduction effects. This proposal describes a plan to make the best possible use of these samples and data and also develop new investigators and projects in the area of aging.
Funding type: research
Funder scheme: R33
Start date: 2021-02-15
End date: 2026-03-14
Investigator: KIM M. HUFFMAN
Institution: DUKE UNIVERSITY
Funded outputs count: 42
Funder award ID: R33AG070455
OpenAlex ID: G9000878701
Biological Pathways of Strength Preservation During Calorie Restriction‐Induced Weight Loss Among Adults Without Obesity
2026 · Nadia Moore, Akshay Bareja, et al. · Obesity
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Caloric restriction improves glycemic control via the adiponectin–ceramide axis in non-obese men and women: the CALERIE™ 2 randomized controlled trial
2026 · Moritz V. Warmbrunn, Raaj Kishore Biswas, et al. · Nature Communications · 1
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An epigenetic speedometer to measure Pace of Aging: FraminghamPACE
2026 · William T Marella, Calen P Ryan, et al. · medRxiv · 1
Self-selected dietary intake and association with achieved caloric restriction in CALERIE ™ 2
2026 · Emily K. Woolf, Kaja Falkenhain, et al. · Critical Reviews in Food Science and Nutrition
Metabolic Adaptations to Caloric Restriction: Time- and Group-Dependent Metabolomic Signatures from the CALERIE™ Trial
2026 · Melissa C. Orenduff, Emily K. Woolf, et al. · Research Square
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Quadriceps mitochondrial DNA quantity, quality, and gene expression after 2 years of calorie restriction: exploratory results from the CALERIE trial
2026 · Jayanta K. Das, Yu Zhang, et al. · GeroScience
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Effect of Caloric Restriction on Predicted Risk of Incident Cardiovascular Disease and Type 2 Diabetes in Young Adults: Findings From the CALERIE 2 Trial
2026 · Ryan Chang, Leanne M. Redman, et al. · Diabetes Obesity and Metabolism
Weight Regain Reverses Caloric Restriction–Induced Benefits on the Insulin–IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial
2026 · Moritz V. Warmbrunn, Lin Yang, et al. · Diabetes Care
Use of Machine Learning to Identify Determinants of Habitual-Preformed Water Intake
2026 · Emma J Stinson, Ethan Collins, et al. · Journal of Nutrition
Effect of 2-Year Caloric Restriction in the Absence of Malnutrition on Indicators of Anemia, Iron Status, and Hepcidin in Healthy Adults: A Randomized Clinical Trial
2026 · Cory Dugan, Sai Krupa Das, et al. · Journal of Nutrition · 1
Lifestyle strategies and mechanistic implications for slowing neurodegeneration
2026 · Jordan A. Gunning, Mario I. Hernandez, et al. · npj Metabolic Health and Disease · 2
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Biological Mechanisms of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Young- to Middle-Aged Adults without Obesity
2026 · Nadia Moore, Akshay Bareja, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Diet quality and nutritional adequacy during a 2-year calorie restriction intervention: the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy 2 trial
2025 · Susan B Racette, Rachel E Silver, et al. · American Journal of Clinical Nutrition · 3
Caloric restriction modifies small RNA profiles and engages age-related molecular pathways in the CALERIE trial
2025 · Melissa C. Orenduff, Kim M. Huffman, et al. · iScience
Dietary Patterns Influence Chronic Disease Risk and Health Outcomes in Older Adults: A Narrative Review
2025 · Jordan A. Gunning, Madeline F. Converse, et al. · Nutrients · 10
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Time-restricted eating in Alzheimer's disease: TREAD pilot trial design
2025 · Susan B. Racette, Jordan A. Gunning, et al. · Contemporary Clinical Trials Communications · 2
Association between physical activity energy expenditure and markers of healthspan during prolonged calorie restriction in individuals without obesity: observations from the CALERIE™ phase 2 randomized controlled trial
2025 · James L. Dorling, Corby K. Martin, et al. · International Journal of Behavioral Nutrition and Physical Activity · 2
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A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study
2025 · Tea Pribić, Jayanta K. Das, et al. · npj Aging · 11
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Increasing the health span: unique role for exercise
2025 · Glenn A. Gaesser, Stephanie E. Hall, et al. · Journal of Applied Physiology · 18
Optimized RNA sequencing deconvolution illustrates the impact of obesity and weight loss on cell composition of human adipose tissue
2025 · Cheehoon Ahn, Adeline Divoux, et al. · Obesity · 10
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The CALERIE Genomic Data Resource
2024 · C. P. Ryan, D. L. Corcoran, et al. · Nature Aging · 13
A 2-year calorie restriction intervention reduces glycomic biological age biomarkers
2024 · Tea Pribić, Jayanta K Das, et al. · medRxiv · 1
Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase
2024 · Carmen Merali, Connor Quinn, et al. · Obesity · 3
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An optimized pipeline for high-throughput bulk RNA-Seq deconvolution illustrates the impact of obesity and weight loss on cell composition of human adipose tissue
2024 · Cheehoon Ahn, Adeline Divoux, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Prediction of individual weight loss using supervised learning: findings from the CALERIETM 2 study
2024 · Christina Glasbrenner, Christoph Höchsmann, et al. · American Journal of Clinical Nutrition · 8
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