Establishment of a new dementia model mouse
Description: In Alzheimer's disease, a type of dementia, accumulation of ubiquitinated proteins is observed within nerve cells. Therefore, we investigated the involvement of the STAM1 molecule of ESCRT-0, which recognizes proteins and is involved in their transport to lysosomes and degradation, in dementia using genetically modified mice. As a result, in a memory behavior test using the Y-maze, STAM1-deficient mice showed decreased memory behavior. Furthermore, when the accumulation of amyloid-β protein in cerebral tissue was examined histochemically, it was found that the accumulation of amyloid-β protein increased with age in STAM1-deficient mice. These results suggest that STAM1-deficient mice have the potential to serve as a new dementia model mouse.
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Kazuko Murata
Institution: Iryo Sosei University
Funded outputs count: 1
Funder award ID: 18K06792
OpenAlex ID: G5469829946