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Strength through diversity? The impact of cell-to-cell variation in gene expression levels during immune aging.

Description: During aging, certain cells become more similar while others become more disparate. The exact consequences of this remain unclear. Does this process better prepare cells for the unexpected? Or does it hinder efficient collaboration between cells? The researcher will determine the consequences of these changes on immune function during aging.

Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Funding type: fellowship

Funder scheme: NWO-Talentprogramma Veni ENW 2019

Start date: 2020-02-01

End date: 2023-06-30

Investigator: Monique Wijst

Institution: Universitair Medisch Centrum Groningen

Funded outputs count: 15

Funder award ID: VI.Veni.192.029

OpenAlex ID: G5492030651

Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction

2024 · Irene V. van Blokland, Roy Oelen, et al. · Circulation Genomic and Precision Medicine · 26

Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammation

2024 · Sergio Andreu-Sánchez, Aida Ripoll-Cladellas, et al. · iScience · 7

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

2023 · Jason A. Hackney, Haridha Shivram, et al. · iScience · 11

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

2023 · Shuang Li, Katharina T. Schmid, et al. · Genome biology · 35

Integration of Candida albicans-induced single-cell gene expression data and secretory protein concentrations reveal genetic regulators of inflammation

2023 · Collins K. Boahen, Roy Oelen, et al. · Frontiers in Immunology · 1

Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels

2022 · Werna T. C. Uniken Venema, Aarón D. Ramírez-Sánchez, et al. · Scientific Reports · 57

Genetic, parental and lifestyle factors influence telomere length

2022 · Sergio Andreu-Sánchez, Geraldine Aubert, et al. · Communications Biology · 81

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure

2022 · Roy Oelen, Dylan H. de Vries, et al. · Nature Communications · 114

Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing

2022 · Christian Huisman, Mason A. Norgard, et al. · Molecular Metabolism · 25

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

2021 · Urmo Võsa, Annique Claringbould, et al. · Nature Genetics · 2,590

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

2021 · Monique G. P. van der Wijst, Sara E. Vazquez, et al. · Science Translational Medicine · 232

Translational insights from single-cell technologies across the cardiovascular disease continuum

2021 · Irene V. van Blokland, Hilde E. Groot, et al. · Trends in Cardiovascular Medicine · 8

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

2020 · Raúl Aguirre-Gamboa, Niek de Klein, et al. · BMC Bioinformatics · 74

Integrating GWAS with bulk and single-cell RNA-sequencing reveals a role for LY86 in the anti-Candida host response

2020 · Dylan H. de Vries, Vasiliki Matzaraki, et al. · PLoS Pathogens · 34

The single-cell eQTLGen consortium

2020 · MGP van der Wijst, DH de Vries, et al. · eLife · 219