Functional analysis of GCN1L1 in mitochondrial stress response
Description: Gcn1 is ribosome binding protein which mediates translational attenuation and amino acid synthesis in response to amino acid starvation. Since Gcn1 knockout mice show embryonic growth retardation and lethality, current study analyzed the phenotype of conditional Gcn1 knockout (CKO) mice employing tamoxifen-inducible Cre and Gcn1 flox mice. Gcn1 CKO mice generated by tamoxifen administration showed decrease in the body weight and accompanying decreases in blood glucose, liver weight and lipid content, and white adipose tissue weight. These data implicates Gcn1 is involved in resistance to tamoxifen toxicity and metabolic homeostasis.
Amount: ¥4,160,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Shuya Kasai
Institution: Hirosaki University
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 2
Funder award ID: 18K06910
OpenAlex ID: G5492867669