Development of an imaging probe targeting receptor for advanced glycation end-products (RAGE): Challenge to overcoming false-positive results of amyloid PET
Description: The present study aimed to develop an imaging probe targeting receptor for advanced glycation end-products (RAGE). A novel radioiodinated probe targeting RAGE was successfully synthesized. Age-related changes in expression level of RAGE and nicotinic acetylcholine receptors (nAChRs) were also examined in a transgenic mouse model of Alzheimer’s disease. The present study revealed an increase in RAGE expression and decrease in alpha4beta2-nAChR expression according to aging. Expression level of alpha7-nAChRs did not change during aging, although it was higher in the transgenic mice compared to wild-type mice.
Amount: ¥3,380,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Exploratory Research
Start date: 2016-04-01
End date: 2018-03-31
Investigator: Masashi UEDA
Institution: Okayama University
Subfield: Clinical Biochemistry
Domain: Life Sciences
Funded outputs count: 1
Funder award ID: 16K15583
OpenAlex ID: G5494737141