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GRK1739

Funded outputs count: 34
Funder award ID: GRK1739
OpenAlex ID: G5501712104
Reversing regulatory safeguards: Targeting the ATR pathway to overcome PARP inhibitor resistance
2025 · Xixi Lin, Ye Qiu, et al. · Molecular Therapy Oncology · 5
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α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells
2024 · Kexu Xiang, Mikhail Kunin, et al. · Cell Death Discovery · 18
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New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement
2023 · Emil Mladenov, Veronika Mladenova, et al. · International Journal of Molecular Sciences · 49
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Low CDK Activity and Enhanced Degradation by APC/CCDH1 Abolishes CtIP Activity and Alt-EJ in Quiescent Cells
2023 · Fanghua Li, Emil Mladenov, et al. · Cells · 11
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The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G2-Checkpoint Activation in Cells Exposed to Ionizing Radiation
2023 · Daxian Luo, Emil Mladenov, et al. · Cells · 4
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Combined radiation- and immune checkpoint-inhibitor-induced pneumonitis – The challenge to predict and detect overlapping immune-related adverse effects from evolving laboratory biomarkers and clinical imaging
2023 · Nika Guberina, Florian Wirsdörfer, et al. · Neoplasia · 18
BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy
2022 · Aashish Soni, Xixi Lin, et al. · Cancers · 10
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The suppression of alt-EJ in quiescent G0-phase cells is caused by enhanced APC/CCDH1-mediated CtIP degradation and low CDK levels
2022 · Fanghua Li, Emil Mladenov, et al. · Research Square
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Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity
2022 · Kexu Xiang, Christian Kalthoff, et al. · Cell Death and Disease · 17
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Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation
2022 · Isabell Goetting, Safa Larafa, et al. · Frontiers in Oncology · 3
ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
2022 · Aashish Soni, Xiaolu Duan, et al. · International Journal of Molecular Sciences · 13
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Stromal Fibroblasts Counteract the Caveolin-1-Dependent Radiation Response of LNCaP Prostate Carcinoma Cells
2022 · Alina Wittka, Julia Ketteler, et al. · Frontiers in Oncology · 9
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Shift in G1-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation
2021 · Fanghua Li, Emil Mladenov, et al. · Cells · 13
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Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA
2021 · Lisa Marie Krieger, Emil Mladenov, et al. · International Journal of Molecular Sciences · 7
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Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types
2021 · Qi Liu, Luis Palomero, et al. · Science Translational Medicine · 57
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Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity
2020 · Alina V. Meyer, Diana Klein, et al. · Frontiers in Oncology · 7
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The vascular nature of lung-resident mesenchymal stem cells
2020 · Jennifer Steens, Lea Klar, et al. · Stem Cells Translational Medicine · 43
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SCFSKP2 regulates APC/CCDH1-mediated degradation of CTIP to adjust DNA-end resection in G2-phase
2020 · Fanghua Li, Emil Mladenov, et al. · Cell Death and Disease · 15
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DSB clusters impair the efficiency of both homologous recombination and c-NHEJ and initiate Rad52 dependent error prone processing
2020 · Chaudhary, Shipra · DuEPublico (University of Duisburg-Essen)
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Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells
2020 · Christine Hansel, Verena Jendrossek, et al. · International Journal of Molecular Sciences · 85
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Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor–stroma interactions
2020 · Julia Ketteler, Alina Wittka, et al. · Cell Death and Disease · 49
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Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
2019 · Emil Mladenov, Christian Staudt, et al. · Nucleic Acids Research · 53
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Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer
2019 · George Iliakis, Emil Mladenov, et al. · Cancers · 103
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The CD73/Ado System—A New Player in RT Induced Adverse Late Effects
2019 · Simone de Leve, Florian Wirsdörfer, et al. · Cancers · 26
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DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells
2019 · Emil Mladenov, Xiaoxiang Fan, et al. · Scientific Reports · 35
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