Award

Defining the functional impact of T1D genes in mouse and man: a unified strategy

Description: T1D is a disease leading to a lifelong requirement for treatment with insulin, and the potential for devastating complications later in life. Genes are known to contribute to the risk of disease, how these genes lead to disease requires an understanding of their functional impact. In this grant we propose a novel strategy that will speed our understanding of how genes known to be associated with T1D lead to this disease; such knowledge will assist future research, but also assist in developing diagnostic and therapeutics for individuals at risk of or with T1D.
Funding type: grant
Funder scheme: DP3
Start date: 2012-09-15
End date: 2017-03-14
Investigator: JANE HOYT BUCKNER
Institution: BENAROYA RESEARCH INST AT VIRGINIA MASON
Subfield: Genetics
Funded outputs count: 33
Funder award ID: DP3DK097672
OpenAlex ID: G3665074854
2024 · Amanda J. Stock, Pierina Gonzalez-Paredes, et al. · Frontiers in Immunology · 11
2022 · Anne M. Hocking, Jane H. Buckner · Frontiers in Immunology · 34
2021 · Eric J Allenspach, Nicholas J Shubin, et al. · The Journal of Immunology · 13
2020 · Harriet A. Purvis, Fiona Clarke, et al. · Frontiers in Immunology · 13
2019 · Jacquelyn A. Gorman, Christian Hundhausen, et al. · Frontiers in Immunology · 51
2018 · Samuel W. Du, Tanvi Arkatkar, et al. · European Journal of Immunology · 72
2018 · Michelle N. Wray-Dutra, Fahd Al Qureshah, et al. · The Journal of Experimental Medicine · 52
2018 · Michelle N. Wray-Dutra, Raghav Chawla, et al. · The Journal of Experimental Medicine · 18
2018 · Cristina Sanchez-Blanco, Fiona Clarke, et al. · Journal of Autoimmunity · 22
2018 · Tanvi Arkatkar, Holly M. Jacobs, et al. · Kidney International · 22
2017 · Harriet A Purvis, Fiona Clarke, et al. · European Journal of Immunology · 25
2017 · Tanvi Arkatkar, Samuel W. Du, et al. · The Journal of Experimental Medicine · 267
2017 · Katharine Schwedhelm, Jerill Thorpe, et al. · Clinical Immunology · 11
2017 · David J. Rawlings, Genita Metzler, et al. · Nature reviews. Immunology · 310
2016 · Shaun W Jackson, Nicole E Scharping, et al. · The Journal of Immunology · 48
2016 · Shaun W. Jackson, Holly M. Jacobs, et al. · The Journal of Experimental Medicine · 207
2016 · Holly M Jacobs, Christopher D Thouvenel, et al. · The Journal of Immunology · 52
2016 · European Journal of Immunology
2015 · Genita Metzler, Nikita S Kolhatkar, et al. · Current Opinion in Immunology · 21
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