Elucidating mechanisms of aging regulation via tryptophan-niacin metabolism
Description: During this research period, tryptophan-niacin (Trp-NAD) metabolism that produces niacin (NA), a kind of vitamin B group, from L-Trp, a kind of amino acid, is related to aging mechanism and affected by phyto-chemicals contained vegetables and fruits were clarified.In the results of in vitro, it was found that insulin and mTOR, which are hormones and regulation factors involved in the aging regulation mechanism, do not directly affect the gene expression of ACMSD, which is a major enzyme of Trp-NAD metabolism, On the other hands, the longevity genes SIRT1 and ACMSD were similar to the gene expression behavior in vivo . Similar results were obtained in the study using curcumin.
Amount: ¥4,030,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Hiroko Matsuda
Institution: Nippon Veterinary and Life Science University(2018-2019)Tokyo University of Marine Science and Technology(2016-2017)
Funded outputs count: 0
Funder award ID: 16K21037
OpenAlex ID: G5521821744