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Identification of the biomarkers that predict frailty and sarcopenia in the elderly

Description: 申請者らがデータベースを構築したコホート集団を用い、骨粗鬆症、変形性関節症、肥満、認知症に関与する液性因子の血中濃度を測定し、疾患との関連を明らかにし、新規診断マーカーとしての意義を検討すると同時に創薬の可能性も検討する。さらに新規コホートスタディーも構築する。申請者が施設長を務める介護老人保健施設入所者とデイケア・リハビリテーション利用者を対象とする。新規参加者に関しては、筋力維持ならびに筋力強化トレーニングの介入を行い、リハビリテーション介入により身体機能ならびに認知機能の改善が認められた対象者のバイオマーカーを抽出し、リハビリテーション効果を予測するバイオマーカーの探索と同定も行う。
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2020-04-01
End date: 2023-03-31
Investigator: Tomohiko Urano
Institution: International University of Health and Welfare
Funded outputs count: 29
Funder award ID: 20K07789
OpenAlex ID: G5570327273
2023 · Ryo Sato, Yohei Sawaya, et al. · Geriatrics and gerontology international/Geriatrics & gerontology international · 4
2023 · Katsuhiko Takahashi, Hitoshi Amano, et al. · PLoS ONE
2023 · Masataka Shiraki, Tatsuhiko Kuroda, et al. · PLoS ONE · 2
2023 · Tamaki Hirose, Yohei Sawaya, et al. · Journal of the American Geriatrics Society · 40
2023 · Ryo Sato, Yohei Sawaya, et al. · Journal of Physical Therapy Science · 1
2022 · Yohei Sawaya, Tamaki Hirose, et al. · International Journal of Environmental Research and Public Health · 6
2022 · Masafumi Itokazu, Masahiro Ishizaka, et al. · International Journal of Environmental Research and Public Health · 14
2022 · Ryo Sato, Yohei Sawaya, et al. · Geriatrics and gerontology international/Geriatrics & gerontology international · 3
2022 · Tamaki Hirose, Yohei Sawaya, et al. · International Journal of Environmental Research and Public Health · 11
2022 · Tamaki Hirose, Yohei Sawaya, et al. · Geriatrics and gerontology international/Geriatrics & gerontology international · 18
2022 · Gotaro Kojima, Yu Taniguchi, et al. · Maturitas · 22
2022 · Ryo Sato, Yohei Sawaya, et al. · Geriatric Nursing · 8
2022 · Yohei Sawaya, Tamaki Hirose, et al. · Geriatrics and gerontology international/Geriatrics & gerontology international · 11
2022 · Gotaro Kojima, Yu Taniguchi, et al. · Journal of the American Geriatrics Society · 23
2022 · Yuta Sugita, Tsuyoshi Hara, et al. · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · 3
2022 · Miho Sato, Takahiro Shiba, et al. · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · 1
2022 · Takahiro Shiba, Yohei Sawaya, et al. · Journal of Physical Therapy Science · 5
2021 · Miyoko Watanabe, Masahiro Ishizaka, et al. · Geriatrics and gerontology international/Geriatrics & gerontology international · 6
2021 · G. Kojima, Y. Taniguchi, et al. · The Journal of Frailty & Aging · 18
2021 · Masaki Nakano, Yukio Nakamura, et al. · The Journal of Clinical Endocrinology & Metabolism · 8
2021 · Takahiro Shiba, Miho Sato, et al. · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · 3
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