Get started
Award

Nutrient Sensing, Hematopoietic Stem Cell Metabolism and Aging

Description: Project Narrative Calorie restriction, the most robust dietary intervention that extends lifespan in mammals, improves hematopoietic stem cell (HSC) function. This project details a study that will elucidate how mitochondrial metabolic homeostasis is maintained during calorie restriction and how dysregulation of this process leads to the functional decline of HSCs during aging. This study will have profound implications in drug development for preventing bone marrow failure, improving injury repair, and preventing diseases of hematopoietic stem cell origin.
Funding type: research
Funder scheme: R01
Start date: 2018-09-15
End date: 2025-05-31
Investigator: DANICA CHEN
Institution: UNIVERSITY OF CALIFORNIA BERKELEY
Subfield: Hematology
Field: Medicine
Funded outputs count: 21
Funder award ID: R01AG063404
OpenAlex ID: G8506283633
Late-life semaglutide treatment slows ageing and extends lifespan in female mice
2026 · Yufan Feng, Marine Barthez, et al. · Nature · 5
Trained immunity links hematopoietic stem cell aging to aging-associated inflammation
2026 · Wei-Chieh Mu, Marine Barthez, et al. · Nature Aging · 3
PDF
SIRT2 and NAD + Boosting Broadly Suppress Aging‐Associated Inflammation
2025 · Marine Barthez, Zehan Song, et al. · Aging Cell · 9
PDF
Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline
2025 · Won-Suk Song, Xiyu Shen, et al. · Cell Metabolism · 17
SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19
2025 · Marine Barthez, Biyun Xue, et al. · Cell Reports · 12
Regulation of Stem Cell Function by NAD +
2025 · Yufan Feng, Huixian Qiu, et al. · Physiology · 3
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
2024 · Yu-Xuan Lyu, Qiang Fu, et al. · Aging · 45
PDF
An NAD+-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging
2024 · Zehan Song, Sang Hee Park, et al. · Nature Aging · 49
PDF
Mitochondrial regulation in stem cells
2023 · Yifei Wang, Marine Barthez, et al. · Trends in Cell Biology · 51
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging
2023 · Chih-Ling Wang, Rika Ohkubo, et al. · Cell Metabolism · 70
The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
2022 · Rika Ohkubo, Wei-Chieh Mu, et al. · Cell Reports · 24
The therapeutic promises of NAD+ boosters
2021 · Claudia Montllor-Albalate, Zehan Song, et al. · Cell Metabolism · 9
PDF
Redox signaling in stem cells and implications for regenerative medicine
2021 · Danica Chen · Free Radical Biology and Medicine · 2
Stem Cell Metabolism and Diet
2020 · Marine Barthez, Zehan Song, et al. · Current Stem Cell Reports · 3
The inherent challenges of classifying senescence—Response
2020 · Stuart R. G. Calimport, Barry L. Bentley, et al. · Science · 5
PDF
The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation
2020 · Wei-Chieh Mu, Rika Ohkubo, et al. · Mechanisms of Ageing and Development · 22
An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance
2020 · Ming He, Hou-Hsien Chiang, et al. · Cell Metabolism · 425
PDF
Latest advances in aging research and drug discovery
2019 · Daniela Bakula, Andrea Ablasser, et al. · Aging · 27
PDF
To help aging populations, classify organismal senescence
2019 · Stuart R. G. Calimport, Barry L. Bentley, et al. · Science · 67
The Epigenetics of Stem Cell Aging Comes of Age
2019 · Danica Chen, Candace Kerr · Trends in Cell Biology · 61
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging
2019 · Hanzhi Luo, Wei-Chieh Mu, et al. · Cell Reports · 161
PDF
Year
Topic