Award

DK105015

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Funded outputs count: 15

Funder award ID: DK105015

OpenAlex ID: G5582335657

Harmine Plus Exendin-4 Enhances Remission of Recent-Onset Type 1 Diabetes Following Anti-CD3 Therapy

2026 · Geming Lu, Randy Kang, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors

2024 · Esra Karakose, Xuedi Wang, et al. · Cell Reports Medicine · 18

A Phase 1 single ascending dose study of pure oral harmine in healthy volunteers

2024 · Jessica L Ables, Leah Israel, et al. · Journal of Psychopharmacology · 20

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system

2024 · Carolina Rosselot, Yansui Li, et al. · Science Translational Medicine · 30

Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal

2023 · Lauryn Choleva, Peng Wang, et al. · Endocrinology · 3

Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms

2023 · Randy B. Kang, Jungeun Lee, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2

Single Cell RNA-Seq Analysis of Regenerative Drug-Treated Human Pancreatic Islets Identifies A Cycling Alpha Cell Population As Key Beta Cell Progenitors

2023 · Esra Karakose, Xuedi Wang, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2

Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile

2022 · Randy B. Kang, Yansui Li, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2

What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series

2021 · Klaus H. Kaestner, Martha Campbell–Thompson, et al. · Molecular Metabolism · 32

Human Beta Cell Regenerative Drug Therapy for Diabetes: Past Achievements and Future Challenges

2021 · Peng Wang, Esra Karakose, et al. · Frontiers in Endocrinology · 52

Nrf2 Regulates β-cell Mass by Suppressing Cell Death and Promoting Proliferation

2021 · Sharon Baumel-Alterzon, Liora S. Katz, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1

The many lives of Myc in the pancreatic β-cell

2020 · Carolina Rosselot, Sharon Baumel-Alterzon, et al. · Journal of Biological Chemistry · 27

A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes

2020 · Alexandra Alvarsson, Maria Jimenez-Gonzalez, et al. · Science Advances · 71

Human Beta Cell Mass Expansion In Vivo With A Harmine and Exendin-4 Combination: Quantification and Visualization By iDISCO+ 3D Imaging

2020 · Carolina Rosselot, Alexandra Alvarsson, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 7

Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor

2020 · Kunal Kumar, Peng Wang, et al. · Journal of Medicinal Chemistry · 55