Get started
Award

91816631

Funder: ZonMw
Funded outputs count: 24
Funder award ID: 91816631
OpenAlex ID: G5583208403
Development of Reliable and High‐Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options
2025 · Ilja Boone, Evelyn Houtman, et al. · Journal of Orthopaedic Research® · 8
PDF
Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants
2025 · Margo Tuerlings, Evelyn Houtman, et al. · Arthritis Research & Therapy · 1
PDF
The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality
2024 · Ghazaleh Hajmousa, Rodrigo Coutinho de Almeida, et al. · Clinical Epigenetics · 10
PDF
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
2024 · Niek G. C. Bloks, Amanda Dicks, et al. · Clinical Epigenetics · 3
PDF
A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading
2022 · Niek GC Bloks, Zainab Harissa, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
PDF
WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes
2022 · M. Tuerlings, G.M.C. Janssen, et al. · Osteoarthritis and Cartilage · 13
PDF
Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis
2022 · Rodrigo Coutinho de Almeida, Margo Tuerlings, et al. · Lara D. Veeken · 16
PDF
Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants
2022 · Marcella van Hoolwerff, Margo Tuerlings, et al. · Lara D. Veeken · 15
PDF
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization
2022 · Alejandro Rodríguez Ruiz, Marcella van Hoolwerff, et al. · Lara D. Veeken · 21
PDF
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes
2022 · Evelyn Houtman, Margo Tuerlings, et al. · Lara D. Veeken · 7
PDF
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis
2022 · Georgia Katsoula, Julia Steinberg, et al. · Human Molecular Genetics · 30
PDF
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II
2021 · Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, et al. · Science Advances · 40
PDF
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
2021 · Margo Tuerlings, Marcella van Hoolwerff, et al. · Lara D. Veeken · 18
PDF
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants
2021 · Evelyn Houtman, Margo Tuerlings, et al. · Arthritis Research & Therapy · 33
PDF
Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells
2021 · Alejandro Rodríguez Ruiz, Amanda Dicks, et al. · Cell and Tissue Research · 41
PDF
The role of TNFRSF11B in development of osteoarthritic cartilage
2021 · Alejandro Rodríguez Ruiz, Margo Tuerlings, et al. · Lara D. Veeken · 27
PDF
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis
2021 · Evelyn Houtman, Marcella van Hoolwerff, et al. · Rheumatology and Therapy · 24
PDF
RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets
2020 · Margo Tuerlings, Marcella van Hoolwerff, et al. · Arthritis & Rheumatology · 61
PDF
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration
2020 · Rodrigo Coutinho de Almeida, Ahmed Mahfouz, et al. · Lara D. Veeken · 33
PDF
Elucidating Epigenetic Regulation by Identifying Functional cis‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage
2020 · Marcella van Hoolwerff, Paula I. Metselaar, et al. · Arthritis & Rheumatology · 32
PDF
Elucidating another level of epigenetic regulation in osteoarthritis by identifying functional cis -acting long non-coding RNAs and their targets in articular cartilage
2020 · Marcella van Hoolwerff, Paula I. Metselaar, et al. · bioRxiv (Cold Spring Harbor Laboratory)
PDF
RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage
2019 · Rodrigo Coutinho de Almeida, Yolande F M Ramos, et al. · Annals of the Rheumatic Diseases · 169
PDF
Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage
2018 · Wouter den Hollander, Irina Pulyakhina, et al. · Arthritis & Rheumatology · 38
PDF
ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone
2018 · Frederique M. F. Cornelis, Silvia Monteagudo, et al. · Science Translational Medicine · 39
PDF
Year
Topic