Neuroimaging Assessments of Brain Integrity in Aging Mice
Description: PUBLIC HEALTH RELEVANCE: The purpose of the study is to use multimodal neuroimaging methods (PET, MRI and MRS) to investigate the brain integrity of aging mice and identify possible protective effects of caloric restriction (CR). The findings from the study will advance our understanding on the interplay between brain metabolic, structural and cognitive functions in aging. In addition, brain metabolism observed in long-lived animal models (e.g., with CR) might predict positive cognitive outcomes in humans. The findings are thus expected to be applicable to the health of human beings, especially for aging and age-related neurodegenerative disorders.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K01
Start date: 2012-08-15
End date: 2017-07-31
Investigator: AI-LING LIN
Institution: UNIVERSITY OF KENTUCKY
Funded outputs count: 34
Funder award ID: K01AG040164
OpenAlex ID: G5014487429