Mechanisms Underlying Benefits of Exercise on Striatal Dopamine Release
Description: Parkinson's disease (PD) affects both sexes and is a disorder of aging. Our preliminary studies show that exercise can increases striatal dopamine (DA) release in young male and female mice. Moreover, in aged (12 month old) wild type mice of both sexes, exercise led to an increase in DA release, as well as significant improvements in motor speed and coordination. This project will address several open questions, including assessing a role for one pathway through which exercise might influence a brain growth factor (brain-derived neurotrophic factor - BDNF) and consequent DA release (Aim 1), and whether a 28-day voluntary wheel running paradigm boosts DA release and improves motor behavior in PD-model mice as we find in wild type mice (Aim 2). Answering these questions may point to new pathways that could be harnessed for PD therapeutics, as well as providing new mechanistic insight into the beneficial effects of exercise in PD.
Funder: Parkinson's Foundation
Amount: $150,000
Funding type: award
Start date: 2022-06-30
End date: 2023-07-31
Investigators: Margaret Rice, Anthony Carna, Anthony Carna, Shannon Ciprut
Institution: New York University Grossman School of Medicine
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 0
Funder award ID: PF-IMP-941656
OpenAlex ID: G5653387967