Tumor-supporting mechanisms by inflammatory cells with somatic mutations
Description: Inflammatory cells having somatic mutations are thought to invade cancer tissues of patients with solid cancers accompanying clonal hematopoiesis. However, the roles of inflammatory cells with somatic mutations in the initiation and progression of cancers have not been clarified. In the present study, as a model for clonal hematopoiesis with TET2 mutations, B16 melanoma cell line was transplanted subcutaneously to the mice in which Tet2 gene was deficient in inflammatory cells of blood lineage (Tet2 deficient mouse) or control mice. Tumor formation was suppressed in Tet2-deficient mice. Bone marrow-derived suppressor cell and tumor-associated macrophage fractions were decreased in Tet2-deficient mice in the spleen. Since these cells are known to be involved in supporting tumor cells, reduction of these fractions may suppress the growth of melanoma.
Amount: ¥6,240,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2018-06-29
End date: 2020-03-31
Investigator: Mamiko Sakata-Yanagimoto
Institution: University of Tsukuba
Funded outputs count: 6
Funder award ID: 18K19464
OpenAlex ID: G5673926656