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AGE-induced Phenotype of the Retinal Pigment Epithelium

Funding type: research
Funder scheme: R01
Start date: 2001-07-01
End date: 2016-08-31
Investigator: JAMES T HANDA
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 47
Funder award ID: R01EY014005
OpenAlex ID: G2778407092
Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium
2017 · Katayoon B. Ebrahimi, Marisol Cano, et al. · Antioxidants and Redox Signaling · 35
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
2017 · Sayantan Datta, Marisol Cano, et al. · Progress in Retinal and Eye Research · 810
Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration
2016 · James T. Handa, Marisol Cano, et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 112
An easy, rapid method to isolate RPE cell protein from the mouse eye
2015 · Hong Wei, Zixian Xun, et al. · Experimental Eye Research · 47
Lysosomes: Regulators of autophagy in the retinal pigmented epithelium
2015 · Debasish Sinha, Mallika Valapala, et al. · Experimental Eye Research · 88
Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society Thesis).
2015 · James T Handa, Mizuki Tagami, et al. · Europe PMC (PubMed Central) · 15
Mice That Produce ApoB100 Lipoproteins in the RPE Do Not Develop Drusen yet Are Still a Valuable Experimental System
2014 · Masashi Fujihara, Marisol Cano, et al. · Investigative Ophthalmology & Visual Science · 38
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Increased L ipocalin‐2 in the retinal pigment epithelium of Cryba1 c KO mice is associated with a chronic inflammatory response
2014 · Mallika Valapala, Malia Edwards, et al. · Aging Cell · 37
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p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium
2014 · Lei Wang, Marisol Cano, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 82
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T Cells and Macrophages Responding to Oxidative Damage Cooperate in Pathogenesis of a Mouse Model of Age-Related Macular Degeneration
2014 · Fernando Cruz-Guilloty, Ali M. Saeed, et al. · PLoS ONE · 66
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Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling
2014 · Mallika Valapala, Christine Wilson, et al. · Autophagy · 144
Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells
2014 · Lei Wang, Naoshi Kondo, et al. · Free Radical Biology and Medicine · 89
Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells
2014 · Marisol Cano, Lei Wang, et al. · Free Radical Biology and Medicine · 102
Oxidized Low-Density-Lipoprotein-Induced Injury in Retinal Pigment Epithelium Alters Expression of the Membrane Complement Regulatory Factors CD46 and CD59 through Exosomal and Apoptotic Bleb Release
2014 · Katayoon B. Ebrahimi, Natalia Fijalkowski, et al. · Advances in experimental medicine and biology · 36
Nrf2 signaling is impaired in the aging RPE given an oxidative insult
2013 · Mira M. Sachdeva, Marisol Cano, et al. · Experimental Eye Research · 207
Role of Unfolded Protein Response Dysregulation in Oxidative Injury of Retinal Pigment Epithelial Cells
2013 · Chen Chen, Marisol Cano, et al. · Antioxidants and Redox Signaling · 67
Retinal Microenvironment Imbalance in Dry Age-Related Macular Degeneration: A Mini-Review
2013 · Brad P. Barnett, James T. Handa · Gerontology · 18
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age‐related macular degeneration
2012 · Katayoon B Ebrahimi, Natalia Fijalkowski, et al. · The Journal of Pathology · 135
Poly(β-Amino Ester)-Nanoparticle Mediated Transfection of Retinal Pigment Epithelial Cells In Vitro and In Vivo
2012 · Joel C. Sunshine, Sarah B. Sunshine, et al. · PLoS ONE · 96
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How does the macula protect itself from oxidative stress?
2012 · James T. Handa · Molecular Aspects of Medicine · 153
Natural History of Age-Related Retinal Lesions That Precede AMD in Mice Fed High or Low Glycemic Index Diets
2011 · Karen A. Weikel, Paul FitzGerald, et al. · Investigative Ophthalmology & Visual Science · 55
Glycation‐altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age‐related disease (in nondiabetics)
2011 · Tomoaki Uchiki, Karen A. Weikel, et al. · Aging Cell · 200
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Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
2011 · David Weismann, Karsten Hartvigsen, et al. · Nature · 533
Advanced Glycation Endproduct Changes to Bruch's Membrane Promotes Lipoprotein Retention by Lipoprotein Lipase
2011 · Marisol Cano, Natalia Fijalkowski, et al. · American Journal Of Pathology · 25
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Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury
2011 · Yanhong Wei, Junsong Gong, et al. · Free Radical Biology and Medicine · 145
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