Chromatin's Role in Repair of Radiation-induced Damage
Description: NARRATIVE Despite the fundamental importance of maintaining genomic stability, there are still huge gaps in our knowledge of the biological processes that maintain genomic stability and the repair of radiation damage. Understanding how packaging our genome into chromatin influences these process will provide key insights into their regulation. The proposed studies will fill these knowledge gaps by uncovering the nature and role of novel intermediates in the repair process that we have uncovered, and will leverage these discoveries to identify targeted therapies to maintain genomic stability in the face of radiation.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2002-05-01
End date: 2025-05-31
Investigator: JESSICA K TYLER
Institution: WEILL MEDICAL COLL OF CORNELL UNIV
Funded outputs count: 72
Funder award ID: R01CA095641
OpenAlex ID: G4380169263