Get started
Award

活性维生素d通过调节细胞衰老发挥抗衰老和抗肿瘤双重作用的机制研究

Amount: ¥2,700,000
Funding type: research
Funder scheme: 重点项目
Start date: 2012-01-01
End date: 2017-12-31
Investigator: 登顺 苗
Institution: 南京医科大学
Funded outputs count: 24
Funder award ID: 81230009
OpenAlex ID: G5726341577
Bmi1 is a key effect molecule of p27-Shh signal pathway in mouse alveolar bone formation
2026 · Ying Yin, Jun Wu, et al. · Scientific Reports
Amniotic membrane mesenchymal stem cells‐based therapy improves Bmi‐1‐deficient mandible osteoporosis through stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption
2022 · Ying Yin, Qiujiao Wang, et al. · Journal of Tissue Engineering and Regenerative Medicine · 8
A Sonic Hedgehog-Gli-Bmi1 signaling pathway plays a critical role in p27 deficiency induced bone anabolism
2022 · Jun Wu, Rong Wang, et al. · International Journal of Biological Sciences · 13
PDF
Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression
2022 · Jinbo Li, Xing Li, et al. · International Journal of Biological Sciences · 11
PDF
Bmi-1 determines the stemness of renal stem or progenitor cells
2020 · Jiawen Zhou, Ao Chen, et al. · Biochemical and Biophysical Research Communications · 10
TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency
2020 · Haiyun Chen, Hongjie Chen, et al. · Experimental & Molecular Medicine · 149
PDF
SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1,25(OH)2D deficiency
2020 · Haiyun Chen, Xiaoqing Hu, et al. · International Journal of Biological Sciences · 47
PDF
1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis
2019 · Renlei Yang, Jie Chen, et al. · Aging Cell · 133
PDF
The Polycomb Protein Bmi1 Plays a Crucial Role in the Prevention of 1,25(OH)2D Deficiency-Induced Bone Loss
2019 · Haijian Sun, Wanxin Qiao, et al. · Journal of Bone and Mineral Research · 32
RETRACTED: 1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
2019 · Lulu Chen, Renlei Yang, et al. · Aging Cell · 196
PDF
Bmi1 Overexpression in Mesenchymal Stem Cells Exerts Antiaging and Antiosteoporosis Effects by Inactivating p16/p19 Signaling and Inhibiting Oxidative Stress
2019 · Guangpei Chen, Ying Zhang, et al. · Stem Cells · 37
PDF
Pyrroloquinoline Quinone Prevents Estrogen Deficiency-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence
2018 · Qinghe Geng, Haiyan Gao, et al. · International Journal of Biological Sciences · 152
PDF
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
2018 · Wen Sun, Wanxin Qiao, et al. · Metabolism · 134
Overexpressed Sirt1 in MSCs Promotes Dentin Formation in Bmi1-Deficient Mice
2018 · H. Wang, C. Lv, et al. · Journal of Dental Research · 23
1,25‐Dihydroxy vitamin D prevents tumorigenesis by inhibiting oxidative stress and inducing tumor cellular senescence in mice
2018 · Lulu Chen, Renlei Yang, et al. · International Journal of Cancer · 63
Bmi1 Deficient Mice Exhibit Male Infertility
2018 · Xiuliang Dai, Qian Zhang, et al. · International Journal of Biological Sciences · 34
PDF
DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide
2018 · Ying Zhang, Guangpei Chen, et al. · International Journal of Biological Sciences · 21
PDF
RETRACTED ARTICLE: P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency
2017 · Jianliang Jin, Jianguo Tao, et al. · Scientific Reports · 47
PDF
BMI-1 Mediates Estrogen-Deficiency–Induced Bone Loss by Inhibiting Reactive Oxygen Species Accumulation and T Cell Activation
2016 · Jinbo Li, Qian Wang, et al. · Journal of Bone and Mineral Research · 54
PDF
1,25(OH)2D3 Deficiency Induces Colon Inflammation via Secretion of Senescence-Associated Inflammatory Cytokines
2016 · Yun Liu, Lulu Chen, et al. · PLoS ONE · 25
PDF
Deficiency of the parathyroid hormone‐related peptide nuclear localization and carboxyl terminal sequences leads to premature skin ageing partially mediated by the upregulation of p27
2015 · Minyue Jiang, Guangpei Chen, et al. · Experimental Dermatology · 7
Bone marrow ablation demonstrates that estrogen plays an important role in osteogenesis and bone turnover via an antioxidative mechanism
2015 · Chunmin Shi, Jun Wu, et al. · Bone · 35
Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice
2015 · YUANQING HUANG, NING CHEN, et al. · Experimental and Therapeutic Medicine · 16
PDF
p27kip1 deficiency accelerates dentin and alveolar bone formation
2014 · Ying Yin, Qun Wang, et al. · Clinical and Experimental Pharmacology and Physiology · 10
Year
Topic