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Age-related Changes in the Pulmonary Artery

Description: Project Narrative This project will investigate how the pulmonary artery of mice remodels as it grows older. The cellular and protein structure of the pulmonary artery will be measured in young and old pulmonary arteries and compared to changes in how genes are expressed in arteries of the same age. Our goal is to learn how growing older affects the pulmonary arteries of mice in order to advance investigations of human pulmonary arteries and how these changes can make us live longer, healthier lives.
Funding type: research
Funder scheme: R03
Start date: 2022-09-01
End date: 2026-05-31
Investigator: EDWARD P MANNING
Institution: YALE UNIVERSITY
Funded outputs count: 17
Funder award ID: R03AG074063
OpenAlex ID: G1500998897
Oxygen Delivery in the Adult Intensive Care Unit with a Focus on Hyperoxic Acute Lung Injury Pathogenesis and Clinical Manifestations
2026 · Zachary M. Harris, Edward P. Manning · Journal of Intensive Care Medicine
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Inherent Biomechanical Properties of the Lung: In vivo-Ex vivo Comparisons in Mice
2026 · Jack Di Palo, Jonathan T. Ibinson, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Microstructural and Biomechanical Determinants of Biological Aging
2026 · Pramath Doddaballapur, Jack Di Palo, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Biological Aging of the Cardiopulmonary System
2026 · Dongnan Liu, Pramath Doddaballapur, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Growth arrest of thoracic aortic aneurysms in aging Marfan mice
2026 · Colin W. Means, Gavin Mays, et al. · American Journal of Physiology-Heart and Circulatory Physiology
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
2026 · Ruben De Man, Zhongyu Cai, et al. · Aging Cell · 6
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
2026 · Ruben De Man, John E. McDonough, et al. · Nature Communications · 12
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A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation
2026 · Abhay B. Ramachandra, Edward P. Manning · Advances in experimental medicine and biology
Growth Arrest of Thoracic Aortic Aneurysms in Aging Marfan Mice
2025 · Dar Weiss, Colin Means, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Stiffening of the human proximal pulmonary artery with increasing age
2024 · Edward P. Manning, Priti Mishall, et al. · Physiological Reports · 10
Guillain-Barre in the long-term acute care hospital setting: Ventilation does not prolong stay
2024 · Kimberly Weil, Vanessa Baumann, et al. · Journal of Mechanical Ventilation
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Developmental changes in lung function of mice are independent of sex as a biological variable
2024 · Thomas Bärnthaler, Abhay B. Ramachandra, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 13
Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1 -Positive Endothelial Cells
2023 · Jonas C. Schupp, Edward P. Manning, et al. · American Journal of Respiratory and Critical Care Medicine · 17
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A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular Programs
2023 · Ruben De Man, John E McDonough, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 12
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Prognostic variables and decannulation of tracheostomy in the long term acute care environment: A case for clinician driven decision making
2023 · Kimberly Weil, Vanessa Baumann, et al. · Journal of Mechanical Ventilation · 1
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The Association between Beta-Natriuretic Peptide (BNP) Serum Levels and Liberation from Mechanical Ventilation
2023 · Kimberly A Weil · Pulmonary Medicine & Respiratory Research
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis
2022 · Sang-Hun Kim, Taylor S. Adams, et al. · American Journal of Respiratory Cell and Molecular Biology · 10
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