Role of estrogen receptor-a in aging and sex-specific responses to 17a-estradiol
Description: PROJECT NARRATIVE The overall goal of this project is to determine what role estrogen receptor α plays in determining lifespan, healthspan, disease burden, and responsiveness to 17α-estradiol, a lifespan-extending compound, in both male and female mice. We will study the effects of whole body and hypothalamic-specific ablation of estrogen receptor α, the stimulation of estrogen receptor α containing cells in the hypothalamus, and the ablation of endogenous estrogen production. This project will provide significant insight into sexually divergent mechanisms of aging, which is currently a critical barrier to developing sex-specific novel treatments aimed at combating aging and chronic diseases in humans.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2021-09-01
End date: 2027-06-30
Investigator: MICHAEL B STOUT
Institution: OKLAHOMA MEDICAL RESEARCH FOUNDATION
Funded outputs count: 16
Funder award ID: R01AG070035
OpenAlex ID: G9000884394