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The pathogenic role of a placenta-specific protease in early-onset preeclampsia

Description: Preeclampsia (PE) is a life-threatening disorder of pregnancy. If left untreated, PE will lead to maternal as well as fetal death. Unfortunately, the only current effective “cure” for PE is to deliver the baby prematurely. The causes of PE are intrinsically related to the placenta, the organ that connects the fetus to the mother. This project will investigate a unique enzyme that is produced only by the placenta, its contribution to PE and its potential as a target for PE treatment.
Amount: A$602,000
Funding type: research
Funder scheme: Project Grants - Standard Project Grant
Start date: 2016-01-01
End date: 2018-12-31
Investigator: A/Pr Nie
Institution: Monash University
Funded outputs count: 12
Funder award ID: 1108365
OpenAlex ID: G5751847711
2019 · Daniel Lorber Rolnik, Yao Wang, et al. · Journal of Perinatology · 1
2019 · Harmeet Singh, Guiying Nie · bioRxiv (Cold Spring Harbor Laboratory)
2016 · Yao Wang, Ying Li, et al. · SLAS DISCOVERY · 14
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