Brown adipose tissue dysfunction promotes metabolic disorder in a failing heart.
Description: Brown adipose tissue (BAT) was initially characterized as an organ involved in thermogenic response, and studies suggest that BAT has crucial roles for the maintenance of systemic metabolic health. In this study, we tried to show the role of BAT in heart failure. TAC operation led to a significant reduction both in intraperitoneal and subcutaneous temperature. TUNEL-positive cells significantly increased in BAT during left ventricular (LV)-pressure overload. Gain of BAT function model improved thermogenesis and ameliorated cardiac dysfunction in TAC. In contrast, genetic model of BAT dysfunction promoted cardiac dysfunction. Metabolomic analyses showed that BAT dysfunction led to an increase in circulating choline level, and an increase in oxidized choline promoted metabolic dysfunction in the failing heart. Maintenance of BAT homeostasis and suppression of oxidized choline would become a novel therapeutic target for heart failure.
Amount: ¥24,050,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (A)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Ippei Shimizu
Institution: Niigata University
Funded outputs count: 8
Funder award ID: 16H06244
OpenAlex ID: G5768501635