XBP1s and Resveratrol regulate the BMSCs'support of myeloma growth and osteoclast
Description: The primary goals of this research proposal are to determine 1) if XBP1s signaling plays a critical role in regulating the capacity of bone marrow stromal cells to support MM cell growth and osteoclastogenesis, and 2) if Resveratrol, an activator of SIRT1 and a bioactive dietary component of red wine, represses XBP1s signaling in BMSCs and compromises their support of MM growth and osteoclastogenesis. These studies will provide important information to develop nutritional and pharmacological strategies involving Resveratrol to reduce MM in humans.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R21
Start date: 2012-06-01
End date: 2015-05-31
Investigator: HONGJIAO OUYANG
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 7
Funder award ID: R21CA161150
OpenAlex ID: G6272547025