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Nitrite Supplementation for Improving Physiological Function in Older Adults

Description: PUBLIC HEALTH RELEVANCE: Nitric oxide (NO) is an essential molecule in the body that decreases with aging and causes reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a compound that increases NO in the body, i.e., sodium nitrite, improves vascular, motor and cognitive function in older adults. The project also seeks to provide insight into the biological reasons (mechanisms) by which supplementation with sodium nitrite improves physiological function in older adults. Overall, this research will provide scientific evidence supporting the use of sodium nitrite for preserving physiological function and preventing clinical disease and disability with aging.
Funding type: research
Funder scheme: R01
Start date: 1996-07-25
End date: 2020-04-30
Investigator: DOUGLAS R SEALS
Institution: UNIVERSITY OF COLORADO
Subfield: Physiology
Field: Medicine
Funded outputs count: 90
Funder award ID: R01AG013038
OpenAlex ID: G5668959924
Repetitive element transcript accumulation is associated with inflammaging in humans
2024 · Meghan E. Smith, Devin Wahl, et al. · GeroScience · 14
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Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes
2022 · Oliver M. Shannon, Tom Clifford, et al. · Nitric Oxide · 51
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Inorganic Nitrite Supplementation Improves Endothelial Function With Aging
2021 · Matthew J. Rossman, Rachel A. Gioscia-Ryan, et al. · Hypertension · 45
Dietary Sodium Restriction Decreases Urinary Ngal in Older Adults with Moderately Elevated Systolic Blood Pressure Free from Chronic Kidney Disease
2020 · Wei Wang, Michel Chonchol, et al. · Journal of Investigative Medicine · 2
Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening
2020 · Rachel A. Gioscia-Ryan, Zachary S. Clayton, et al. · GeroScience · 25
Aerobic exercise training and vascular function with ageing in healthy men and women
2019 · Douglas R. Seals, Erzsebet E. Nagy, et al. · The Journal of Physiology · 231
Sodium Nitrite Supplementation Improves Vascular Endothelial Function but not Motor or Cognitive Function in Middle‐Aged and Older Adults
2019 · Kayla A. Woodward, Jessica R. Santos‐Parker, et al. · The FASEB Journal · 4
Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue
2018 · Dov B. Ballak, Suzhao Li, et al. · Journal of Biological Chemistry · 52
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Strategies for Achieving Healthy Vascular Aging
2018 · Kristen L. Nowak, Matthew J. Rossman, et al. · Hypertension · 152
Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function
2017 · Matthew J. Rossman, Rachelle E. Kaplon, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 232
Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice
2017 · Michael J. Pagliassotti, Andrea L. Estrada, et al. · The Journal of Nutritional Biochemistry · 57
Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice
2016 · Rachel A. Gioscia-Ryan, Micah L. Battson, et al. · Aging · 61
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Nutrition and other lifestyle influences on arterial aging
2016 · Thomas J. LaRocca, Christopher R. Martens, et al. · Ageing Research Reviews · 83
Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults
2016 · Rachelle E. Kaplon, Sierra D. Hill, et al. · Aging · 84
Suppression of the gut microbiome with broad‐spectrum antibiotic cocktail reverses age‐related arterial dysfunction in mice
2016 · James Richey, Lauren Cuevas, et al. · The FASEB Journal
Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise
2016 · G L Pierce, S A Harris, et al. · Journal of Human Hypertension · 37
Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults
2015 · Kristen L. Jablonski, Anthony J. Donato, et al. · Journal of Hypertension · 48
Effect of Dietary Sodium Restriction on Human Urinary Metabolomic Profiles
2015 · Kristen L. Jablonski, Jelena Klawitter, et al. · Clinical Journal of the American Society of Nephrology · 20
Oral nitrite therapy improves vascular function in diabetic mice
2015 · Amy L Sindler, Kimberly Cox-York, et al. · Diabetes and Vascular Disease Research · 13
Translational Geroscience: Emphasizing function to achieve optimal longevity
2014 · Douglas R. Seals, Simon Melov · Aging · 90
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Mitochondrial quality control and age-associated arterial stiffening
2014 · Thomas J. LaRocca, Christopher M. Hearon, et al. · Experimental Gerontology · 81
You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging
2014 · Douglas R. Seals, Rachelle E. Kaplon, et al. · Physiology · 138
Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB
2014 · Ashley E. Walker, Rachelle E. Kaplon, et al. · Clinical Science · 81
Superoxide signaling in perivascular adipose tissue promotes age‐related artery stiffness
2013 · Bradley S. Fleenor, Jason S. Eng, et al. · Aging Cell · 83
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Battery of behavioral tests in mice that models age-associated changes in human motor function
2013 · Jamie N. Justice, Christy S. Carter, et al. · AGE · 128
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