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RNA splicing dysfunction in Alzheimer's disease

Description: PUBLIC HEALTH RELEVANCE: Alzheimer's disease is the sixth leading cause of death in the United Sates, affecting ~5.4 million Americans, but there is no cure for the disease. We propose to investigate the role of RNA splicing dysfunction in the development of Alzheimer's disease. The study will provide important insights into molecular mechanisms of pathogenesis, which may offer new strategies for therapeutic intervention.
Funding type: research
Funder scheme: R01
Start date: 2015-05-01
End date: 2021-04-30
Investigator: JUNMIN PENG
Institution: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Funded outputs count: 58
Funder award ID: R01AG047928
OpenAlex ID: G3616039601
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures
2026 · Him K. Shrestha, Huan Sun, et al. · Cell · 5
Human and mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidome
2025 · Jay M. Yarbro, Xian Han, et al. · Nature Communications · 41
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Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
2022 · Ping-Chung Chen, Xian Han, et al. · Nature Aging · 61
JUMPptm: Integrated software for sensitive identification of post‐translational modifications and its application in Alzheimer's disease study
2022 · Suresh Poudel, David Vanderwall, et al. · PROTEOMICS · 14
Deep Single-Cell-Type Proteome Profiling of Mouse Brain by Nonsurgical AAV-Mediated Proximity Labeling
2022 · Xiaojun Sun, Huan Sun, et al. · Analytical Chemistry · 37
Proteomic Profiling of Cerebrospinal Fluid by 16-Plex TMT-Based Mass Spectrometry
2021 · Kaushik Kumar Dey, Huan Sun, et al. · Methods in molecular biology · 14
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
2021 · David Vanderwall, Poudel Suresh, et al. · Journal of Visualized Experiments · 13
JUMPt: Comprehensive Protein Turnover Modeling of In Vivo Pulse SILAC Data by Ordinary Differential Equations
2021 · Surendhar Reddy Chepyala, Xueyan Liu, et al. · Analytical Chemistry · 20
Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
2021 · Bing Bai, David Vanderwall, et al. · Molecular Neurodegeneration · 258
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An age-downregulated ribosomal RpS28 protein variant regulates the muscle proteome
2021 · Jianqin Jiao, Kanisha Kavdia, et al. · G3 Genes Genomes Genetics · 24
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Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer’s Disease
2021 · Kaiwen Yu, Mingming Niu, et al. · Journal of the American Society for Mass Spectrometry · 15
Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
2021 · Liam C. Hunt, Bronwen Schadeberg, et al. · Nature Communications · 77
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High-Throughput Profiling of Proteome and Posttranslational Modifications by 16-Plex TMT Labeling and Mass Spectrometry
2021 · Kaiwen Yu, Zhen Wang, et al. · Methods in molecular biology · 38
Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry
2020 · Danting Liu, Shu Yang, et al. · Journal of Proteome Research · 35
High-throughput and Deep-proteome Profiling by 16-plex Tandem Mass Tag Labeling Coupled with Two-dimensional Chromatography and Mass Spectrometry
2020 · Zhen Wang, Kanisha Kavdia, et al. · Journal of Visualized Experiments · 19
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease
2020 · Hong Wang, Kaushik Kumar Dey, et al. · Molecular Neurodegeneration · 210
JUMPm: A Tool for Large-Scale Identification of Metabolites in Untargeted Metabolomics
2020 · Xusheng Wang, Ji-Hoon Cho, et al. · Metabolites · 26
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Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression
2020 · Bing Bai, Xusheng Wang, et al. · Neuron · 78
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27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer’s Disease
2020 · Zhen Wang, Kaiwen Yu, et al. · Analytical Chemistry · 120
Novel specialized cell state and spatial compartments within the germinal center
2020 · Domenick E. Kennedy, Michael K. Okoreeh, et al. · Nature Immunology · 100
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression
2020 · Bing Bai, Xusheng Wang, et al. · Neuron · 571
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Faculty Opinions recommendation of Identification of a Functional Non-coding Variant in the GABA A Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research.
2019 · Holger Lerche, Mahmoud Koko Musa · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology
2019 · Kaj Blennow, Chun Chen, et al. · Brain · 105
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Multimodal Imaging of Amyloid Plaques: Fusion of the Single-Probe Mass Spectrometry Image and Fluorescence Microscopy Image
2019 · Xiang Tian, Boer Xie, et al. · Analytical Chemistry · 41
Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
2019 · Hong Wang, Alexander K. Diaz, et al. · Nature Communications · 67
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