Involvement of brain volume and stress-related hormone in cognitive impairment with age-related hearing loss
Description: Of the 36 elderly, the moderate or severe deafness group had higher Cortisol / DHEAS ratio (C/D ratio), albumin, AST, total inflammatory markers ( CRP + IL-6 + TNFa), hippocampal atrophy rate (HP%), and depression score than the normal or mild deafness group. In the partial correlation excluding the effect of age, the C/D ratio, high frequency hearing level, and hippocampal atrophy rate were correlated each other. The average hearing level in the middle frequency range was positively correlated with MDA-LDL and albumin. In the partial correlation whilst controlling for the effects of age and C/D ratio, the correlation between high frequency hearing level and hippocampal atrophy rate disappeared, and high frequency hearing level correlated with DHEAS only. It suggests that high C / D ratio, oxidative stress, and high calories may worsen hearing levels, resulting in hippocampal atrophy and depression.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Mitsuhiro Aoki
Institution: Gifu University
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 0
Funder award ID: 17K00203
OpenAlex ID: G5871116296