Novel treatment for heart failure - cardiomyocytes implantation by using matrix graft
Description: A major problem in myocardial regenerative medicine is the low engraftment rate and survival rate of transplanted cells. The solution is to improve the external environment of the transplanted cells. Cells live within the extracellular matrix (ECM), and with the development of tissue engineering, many artificial ECMs have been developed. In this experiment, cardiomyocytes are cultured on artificial ECM, cardiomyocyte ECM grafts are prepared, and transplanted onto the surface of injured myocardium. The ECM graft also has physical strength and is responsible for mechanical reinforcement. The transplanted cardiomyocytes can then reconstruct the myocardial excitatory propagation impaired in the injured myocardium. Cardiomyocyte ECM graft transplantation is expected to contribute to the improvement of cell transplantation methods, as the application of useful base materials for cell transplantation is also considered in the field of myocardial regenerative medicine.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Yasuo Miyagi
Institution: Nippon Medical School
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Funded outputs count: 0
Funder award ID: 17K10742
OpenAlex ID: G5872310134