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Investigations of molecular mechanisms governing osmosensing and cell stress pathways in nucleus pulposus cells

Description: Saude
Amount: €96,310
Funding type: grant
Funder scheme: POR_NORTE
Start date: 2016-10-01
End date: 2020-11-30
Investigator: Emanuel José Magalhães Novais
Institution: UNIVERSIDADE DO MINHO
Funded outputs count: 6
Funder award ID: PD/BD/128077/2016
OpenAlex ID: G5874488673
Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J mice
2026 · Emanuel J. Novais, Olivia K. Ottone, et al. · Bone Research · 10
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Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J mice
2024 · Emanuel J. Novais, Olivia K. Ottone, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
2021 · Emanuel J. Novais, Victoria A. Tran, et al. · Nature Communications · 440
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Hypoxia and Hypoxia-Inducible Factor-1α Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells
2020 · Emanuel J. Novais, Hyowon Choi, et al. · American Journal Of Pathology · 39
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Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging
2020 · Emanuel J. Novais, Victoria A. Tran, et al. · Aging Cell · 48
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Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration
2020 · Takashi Ohnishi, Emanuel J. Novais, et al. · Matrix Biology Plus · 46
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