Functional changes in brain white matter caused by exposure of addictive drugs
Description: We investigated the effects of addictive drugs on the white matter by focusing on changes in oligodendrocytes and axonal conduction. The effects of methamphetamine, cocaine, and nicotine were studied. We found that there were changes that were common to these drug administrations and changes that were not common. Moreover, we observed that acute and chronic exposure of same drug oppositely affect the axonal conduction. By functional examination of the changes in axonal conduction in myelinated fibers, we discovered the previously unappreciated effects of addictive drugs on the nervous system with their diversity.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2021-03-31
Investigator: Yoshihiko YAMAZAKI
Institution: Yamagata University
Funded outputs count: 9
Funder award ID: 16K01943
OpenAlex ID: G5900926328