Understanding methionine metabolism and its therapeutic potential in cancer
Description: Diet can affect cancer cell metabolism and nutritional requirements to as large a degree as the oncogenes and tumor suppressor genes. Our preliminary data show that a specific dietary methionine restriction has anti-tumor properties alone or in adjuvant therapy in several cancer models. In this proposal I will dissect the nature of methionine restriction mediated anti-cancer effects for its therapeutic application.
Funder: National Cancer Institute
Funding type: career_development
Funder scheme: K99
Start date: 2019-09-19
End date: 2021-08-31
Investigator: XIA GAO
Institution: DUKE UNIVERSITY
Subfield: Biotechnology
Domain: Life Sciences
Funded outputs count: 5
Funder award ID: K99CA237618
OpenAlex ID: G425230068