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Diverse effects of somatopause and aging on the skeleton

Description: NARRATIVE: Our studies focus on somatotropic regulation of bone matrix composition, lacunar canaliculi system, mitochondrial function, and metabolic flexibility in aging osteocytes.
Funding type: research
Funder scheme: R01
Start date: 2018-09-15
End date: 2024-04-30
Investigator: MITCHELL B SCHAFFLER
Institution: NEW YORK UNIVERSITY
Funded outputs count: 20
Funder award ID: R01AG056397
OpenAlex ID: G6893228424
Liver injury severity determines skeletal deterioration: a shared pathophysiological axis between MASLD and osteoarthritis
2025 · Mercedes del Rio-Moreno, Sher Bahadur Poudel, et al. · GeroScience · 4
Canagliflozin-induced adaptive metabolism in bone
2025 · Sher Bahadur Poudel, Carolyn Chlebek, et al. · Diabetes · 7
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The impact of inactivation of the GH/IGF axis during aging on healthspan
2024 · Sher Bahadur Poudel, Ryan R. Ruff, et al. · GeroScience · 9
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In nondiabetic C57BL/6J mice, canagliflozin affects the skeleton in a sex- and age-dependent manner
2024 · Carolyn Chlebek, Casey McAndrews, et al. · JBMR Plus · 6
Deletion of absent in melanoma-2 (AIM2) drives bone marrow adipogenesis and impairs bone microarchitecture
2024 · Zhenwei Gong, Manisha Dixit, et al. · GeroScience · 3
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Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
2024 · Sher Bahadur Poudel, Ryan R Ruff, et al. · Arthritis Research & Therapy · 13
Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging
2024 · Sher Bahadur Poudel, Dorra Frikha-Benayed, et al. · Aging · 12
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Long-term effects of canagliflozin treatment on the skeleton of aged UM-HET3 mice
2023 · Gozde Yildirim, Edmara T. P. Bergamo, et al. · GeroScience · 11
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Excess Growth Hormone Triggers Inflammation-Associated Arthropathy, Subchondral Bone Loss, and Arthralgia
2023 · Sher B. Poudel, Ryan R. Ruff, et al. · American Journal Of Pathology · 17
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Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging
2021 · Manisha Dixit, Silvana Duran‐Ortiz, et al. · Aging Cell · 8
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Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan
2021 · Silvana Duran‐Ortiz, Edward O. List, et al. · Aging Cell · 57
Sexual dimorphic impact of adult‐onset somatopause on life span and age‐induced osteoarthritis
2021 · Sher Bahadur Poudel, Manisha Dixit, et al. · Aging Cell · 11
Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading
2021 · Karl J. Lewis, Pamela Cabahug-Zuckerman, et al. · Bone · 28
A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation
2021 · Abigail A Coffman, Jelena Basta‐Pljakic, et al. · JBMR Plus · 15
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Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties
2020 · Manisha Dixit, Leeann D Louis, et al. · Journal of Bone and Mineral Research · 5
International meeting on GH/IGF actions in the shadow of COVID19
2020 · Shoshana Yakar · Pituitary · 2
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Effects of GH/IGF axis on bone and cartilage
2020 · Manisha Dixit, Sher Bahadur Poudel, et al. · Molecular and Cellular Endocrinology · 216
Effects of GH/IGF on the Aging Mitochondria
2020 · Sher Bahadur Poudel, Manisha Dixit, et al. · Cells · 62
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Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels
2020 · Sean McCutcheon, Robert J Majeska, et al. · Journal of Bone and Mineral Research · 47
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Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice
2018 · Zhongbo Liu, Maria E Solesio, et al. · Journal of Bone and Mineral Research · 37
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