Slowing aging by multiplexing (SLAM)
Description: Narrative. Geropath R01 The goal of this project is to test combinations of known anti-aging drugs in a preclinical mouse model of aging as a way to more effectively prevent or slow aging and make predictions for clinical aging studies. A Geropathology Grading Platform (GGP), based on age-related pathological changes that occur universally in each organ, will be used to generate composite lesion scores that detect attenuation of the rate of aging afforded by drug interventions. Since two to four months of drug intervention is sufficient to elicit a measurable difference in the slope of tissue aging, the GGP is a relatively rapid and sensitive paradigm to test drug combinations that target different molecular pathways.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R56
Start date: 2018-09-30
End date: 2020-08-31
Investigator: WARREN C LADIGES
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 17
Funder award ID: R56AG058543
OpenAlex ID: G8984375282