Identification of gut microbiota- derived metabolites and the mechanisms that impair glucose metabolism
Description: We analyzed plasma and cecal metabolomics data of genetically different mice treated with a high fat- diet and/or antibiotics and identified several metabolites that correlated with insulin resistance of the host（Fujisaka et al. Cell Reports. 22: 3072-3086, 2018）. We also reported that Bofutsushosan (BFT), a Japanese herbal medicine which has been clinically used for constipation in Asian countries, ameliorates glucose metabolism in mice with diet-induced obesity. As the mechanism, we found that BFT modified the gut microbiota, which may contribute to improving gut barrier function and preventing metabolic endotoxemia, leading to attenuation of diet-induced inflammation and glucose intolerance (Fujisaka et al. Sci. Rep. 10: 5544, 2020）.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Shiho Fujisaka
Institution: University of Toyama
Funded outputs count: 7
Funder award ID: 17K09821
OpenAlex ID: G5961184398