Kynurenine accumulation drives loss of muscle and bone function with aging
Description: Loss of muscle and bone mass with age are underlying factors contributing to falls and fractures in the elderly, and these fractures are very costly in terms of both financial burden and quality of life. A critical barrier to progress in correcting the problem of muscle and bone loss with aging is a poor understanding of the molecular and cellular mechanisms underlying age-related musculoskeletal dysfunction. Our goal is to address this problem by providing critical, new information on the molecular and cellular mechanisms that control these processes, and thereby improve scientific knowledge, technical capability, and eventually clinical practice.
Funder: National Institute on Aging
Funding type: program
Funder scheme: P01
Start date: 2011-05-01
End date: 2027-05-31
Investigator: CARLOS M. ISALES
Institution: AUGUSTA UNIVERSITY
Funded outputs count: 162
Funder award ID: P01AG036675
OpenAlex ID: G9000886169