Cell Biology of Astrocyte-Ganglion Cell Interactions in the Retina and Optic Nerve
Description: Project Narrative Secreted phosphoprotein 1 (SPP1) shows neuroprotective activity in mouse models of glaucoma and also slows retinal ganglion cell loss that occurs with normal aging. In astrocytes, SPP1 increases mitochondrial function, delivery of ATP from the mitochondria to the cytoplasm, and reduces the expression of inflammatory mediators. SPP1, or small molecules that increase SPP1 expression in the eye, may be attractive candidates for neuroprotective therapies in glaucoma and aging.
Funder: National Eye Institute
Funding type: research
Funder scheme: R01
Start date: 2009-09-30
End date: 2029-04-30
Investigator: TATJANA CLAUDIA JAKOBS
Institution: MASSACHUSETTS EYE AND EAR INFIRMARY
Funded outputs count: 21
Funder award ID: R01EY019703
OpenAlex ID: G9000892659