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Impact of metabolic changes in response to chronic cocaine on circadian gene func

Description: PUBLIC HEALTH RELEVANCE: Substance Abuse disorders are devastating diseases and there are very few treatments available. This proposal will help determine how chronic cocaine exposure alters neuronal metabolic states, leading to disruptions in normal transcriptional regulation and the reward value of cocaine.

Funder: National Institute on Drug Abuse

Funding type: research

Funder scheme: R21

Start date: 2014-04-01

End date: 2017-03-31

Investigator: COLLEEN A MCCLUNG

Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

Funded outputs count: 8

Funder award ID: R21DA037636

OpenAlex ID: G7911681181

Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior

2022 · Darius D. Becker-Krail, Kyle D. Ketchesin, et al. · Biological Psychiatry · 42

Circadian transcription factor NPAS2 and the NAD + ‐dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward

2022 · Darius D. Becker‐Krail, Puja K. Parekh, et al. · European Journal of Neuroscience · 15

Cell-type Specific Regulation of Reward-Related Behavior: The Interface of Metabolic State and the Circadian Molecular Clock

2021 · Darius D. Becker‐Krail · D-Scholarship@Pitt (University of Pittsburgh)

Measuring the Effects of Circadian Rhythm-Related Manipulations on Depression-Like Behavior in Rodents: Forced Swim and Tail Suspension Tests

2020 · Chelsea A. Vadnie, Lauren M. DePoy, et al. · Methods in molecular biology · 16

Rhythms of life: circadian disruption and brain disorders across the lifespan

2018 · Ryan W. Logan, Colleen A. McClung · Nature reviews. Neuroscience · 713

NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward

2018 · Ryan W. Logan, Puja K. Parekh, et al. · Molecular Psychiatry · 48

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors

2017 · Angela R. Ozburn, Joseph Kern, et al. · Frontiers in Molecular Neuroscience · 49

Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

2017 · Chelsea A. Vadnie, Colleen A. McClung · Neural Plasticity · 199