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Microbial Nucleic Acid Sensing in Periodontitis

Description: PUBLIC HEALTH RELEVANCE: Current proposal will characterize the involvement of microbial nucleic sensing in periodontal inflammation. The main focus will be TLR9-triggered inflammatory responses. The proposed studies will reveal novel biological pathways and therapeutic targets to control and prevent periodontitis and will lead to future studies to identif novel link between periodontitis and systemic complications.
Funding type: research
Funder scheme: R01
Start date: 2015-06-20
End date: 2021-05-31
Investigator: SINEM ESRA SAHINGUR
Institution: UNIVERSITY OF PENNSYLVANIA
Subfield: Periodontics
Field: Dentistry
Funded outputs count: 22
Funder award ID: R01DE025037
OpenAlex ID: G3485362268
Dasatinib and Quercetin Limit Gingival Senescence, Inflammation, and Bone Loss
2025 · K. Rattanaprukskul, X.-J. Xia, et al. · Journal of Dental Research · 23
Molecular Signatures of Senescence in Periodontitis: Clinical Insights
2024 · K. Rattanaprukskul, X.-J. Xia, et al. · Journal of Dental Research · 42
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells
2023 · Emmanuel Albuquerque‐Souza, Benjamin Shelling, et al. · Molecular Oral Microbiology · 13
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TLR9 Mediates Periodontal Aging by Fostering Senescence and Inflammaging
2022 · E. Albuquerque-Souza, K.E. Crump, et al. · Journal of Dental Research · 34
Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis
2022 · Emmanuel Albuquerque‐Souza, Sinem E. Sahingur · Periodontology 2000 · 162
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Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
2021 · Erin C. Mooney, Sara E. Holden, et al. · Frontiers in Immunology · 57
Editorial: Oral Microbiome and Inflammation Connection to Systemic Health
2021 · Loreto Abusleme, Ana Carolina Morandini, et al. · Frontiers in Cellular and Infection Microbiology · 7
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The Ubiquitin System and A20: Implications in Health and Disease
2020 · E.C. Mooney, S.E. Sahingur · Journal of Dental Research · 96
A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis
2020 · Yajie Li, Erin C. Mooney, et al. · Frontiers in Immunology · 24
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A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-κB Activity
2019 · Yajie Li, Erin C Mooney, et al. · The Journal of Immunology · 27
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Periodontal therapy favorably modulates the oral-gut-hepatic axis in cirrhosis
2018 · Jasmohan S. Bajaj, Payam Matin, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 116
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Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
2017 · Kyung-A Song, Matthew J. Niederst, et al. · Clinical Cancer Research · 96
Microbiota, cirrhosis, and the emerging oral-gut-liver axis
2017 · Chathur Acharya, Sinem Esra Sahingur, et al. · JCI Insight · 256
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Increased expression of toll-like receptors 2 and 9 is associated with reduced DNA methylation in spontaneous preterm labor
2017 · Scott W. Walsh, Anuja A. Chumble, et al. · Journal of Reproductive Immunology · 18
Increasing popularity of waterpipe tobacco smoking and electronic cigarette use: Implications for oral healthcare
2017 · C. P. Ramôa, T. Eissenberg, et al. · Journal of Periodontal Research · 105
Interplay of Toll-Like Receptor 9, Myeloid Cells, and Deubiquitinase A20 in Periodontal Inflammation
2016 · Katie E. Crump, Jennifer C. Oakley, et al. · Infection and Immunity · 64
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Microbial Nucleic Acid Sensing in Oral and Systemic Diseases
2015 · K.E. Crump, S.E. Sahingur · Journal of Dental Research · 53
Toll-Like Receptor 9-Mediated Inflammation Triggers Alveolar Bone Loss in Experimental Murine Periodontitis
2015 · Paul D. Kim, Xia Xia-Juan, et al. · Infection and Immunity · 72
Chemokine Function in Periodontal Disease and Oral Cavity Cancer
2015 · Sinem Esra Sahingur, W. Andrew Yeudall · Frontiers in Immunology · 153
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Novel Inflammatory Pathways in Periodontitis
2014 · G. Hajishengallis, S.E. Sahingur · Advances in Dental Research · 81
Talk to Me, Baby! Supporting Language Development in the First 3 Years.
2008 · Betty Bardige, M. Kori Bardige · Zero to three · 5
Сбалансированная система показателей как инструмент стратегического контроллинга
2007 · К. Г. Цыкин · CyberLeninK (CyberLeninka)
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