Analysis of mechanism of chronological lifespan extension by sulfur depletion in fission yeast
Description: Nutritional restrictions are known to increase the lifespan of various organisms. In this study, we found that sulfur restriction extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The sulfur restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These cellular responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also found that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl11 gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS in fission yeast. Therefore, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner.
Amount: ¥4,940,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Hokuto Ohtsuka
Institution: Nagoya University
Subfield: Aging
Domain: Life Sciences
Funded outputs count: 4
Funder award ID: 16K07662
OpenAlex ID: G6056573930