Award

Identifying and Correcting Dementia-Associated Changes in the Blood-Brain Barrier

Description: Narrative Declining brain vasculature is a key, but understudied, component of several age – associated neurodegenerative disorders including Alzheimer’s disease (AD) and related dementias. The research described in this proposal uses a combination of bioinformatics, mouse studies and human pluripotent stem cell modeling to identify and characterize novel AD-related pathways and factors involved in the maintenance or deterioration of blood vessels and the blood-brain barrier. Identifying factors that slow or reverse the decline of brain vasculature could be a new therapeutic avenue for these devastating and deadly disorders.

Funder: National Institute of Neurological Disorders and Stroke

Funding type: research

Funder scheme: RF1

Start date: 2020-09-01

End date: 2024-08-31

Investigator: LEE L RUBIN

Institution: HARVARD UNIVERSITY

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

Funded outputs count: 1

Funder award ID: RF1NS117407

OpenAlex ID: G7004414144

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

2023 · Methodios Ximerakis, Kristina M. Holton, et al. · Nature Aging · 80

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