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Regulation of the cell cycle and signaling by CUL-2 E3 complexes

Description: Metastatic cancer is caused by the unregulated proliferation of cells that are able to move throughout the body. This proposal addresses how CRL2 protein complexes (which degrade other proteins) act to: inhibit the Ras and Notch signaling pathway that promote cancer; block cell movements; and degrade a central regulator of cell division (cyclin B). This project will provide new insights into fundamental cancer-related processes, and provide the potential for the future development of cancer therapies.

Funder: National Institute of General Medical Sciences

Funding type: research

Funder scheme: R01

Start date: 2007-02-01

End date: 2018-03-31

Investigator: EDWARD T. KIPREOS

Institution: UNIVERSITY OF GEORGIA

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 20

Funder award ID: R01GM074212

OpenAlex ID: G3100716769

The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development

2023 · Mohammad M Rahman, Riju S Balachandran, et al. · Genetics

Developmental Control of the Cell Cycle: Insights from Caenorhabditis elegans

2019 · Edward T Kipreos, Sander van den Heuvel · Genetics · 59

The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity

2018 · Snehal N. Chaudhari, Edward T. Kipreos · BioEssays · 42

Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner

2017 · Madhumati Mukherjee, Snehal N. Chaudhari, et al. · Developmental Biology · 10

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

2017 · Snehal N. Chaudhari, Edward T. Kipreos · Nature Communications · 151

FEM1 proteins are ancient regulators of SLBP degradation

2017 · John F. Dankert, Julia K. Pagan, et al. · Cell Cycle · 34

Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage

2017 · Riju S. Balachandran, Edward T. Kipreos · Molecular & Cellular Oncology · 14

Primary Culture System for Germ Cells from Caenorhabditis elegans Tumorous Germline Mutants

2017 · Alexandra Vagasi, Mohammad Rahman, et al. · BIO-PROTOCOL · 2

The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage

2016 · Riju S. Balachandran, Cassandra S. Heighington, et al. · The Journal of Cell Biology · 45

Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation

2016 · Snehal N. Chaudhari, Madhumati Mukherjee, et al. · Developmental Cell · 46

Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors

2011 · Natalia G. Starostina, Edward T. Kipreos · Trends in Cell Biology · 147

Overcoming Redundancy: An RNAi Enhancer Screen for Morphogenesis Genes in Caenorhabditis elegans

2011 · Jacob M Sawyer, Stephanie Glass, et al. · Genetics · 35

CRL2LRR-1 Targets a CDK Inhibitor for Cell Cycle Control in C. elegans and Actin-Based Motility Regulation in Human Cells

2010 · Natalia G. Starostina, Jennifer M. Simpliciano, et al. · Developmental Cell · 58

MEC-17 is an α-tubulin acetyltransferase

2010 · Jyothi S. Akella, Dorota Wloga, et al. · Nature · 489

C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues

2010 · Dimple R. Bosu, Hui Feng, et al. · Developmental Biology · 36

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

2009 · Bryan T. MacDonald, Keiko Tamai, et al. · Developmental Cell · 5,585

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

2008 · Youngjo Kim, Natalia G. Starostina, et al. · Genes & Development · 240

Control of the Cdc6 replication licensing factor in metazoa: The role of nuclear export and the CUL4 ubiquitin ligase

2008 · Jihyun Kim, Edward T. Kipreos · Cell Cycle · 22

Cullin-RING ubiquitin ligases: global regulation and activation cycles

2008 · Dimple R Bosu, Edward T Kipreos · Cell Division · 309

A CUL-2 Ubiquitin Ligase Containing Three FEM Proteins Degrades TRA-1 to Regulate C. elegans Sex Determination

2007 · Natalia G. Starostina, Jae-min Lim, et al. · Developmental Cell · 141