Get started
Award

Energy Expenditure and Metabolic Effects through Brown/Beige Adipose Clk2 Kinase

Description: Project Narrative Defective energy expenditure due to thermogenic failures in brown and beige adipose tissues causes a major predisposition for obesity and metabolic complications including type 2 diabetes. Conversely, activation of thermogenic activities in these tissues prevents obesity and improves diabetic symptoms. Studies in this grant proposal focusing on the feeding-mediated activation of the protein kinase Clk2 in brown and beige adipose tissues might translate into potential therapies. 1
Funding type: research
Funder scheme: R01
Start date: 2011-04-01
End date: 2023-03-31
Investigator: PERE PUIGSERVER
Institution: DANA-FARBER CANCER INST
Subfield: Physiology
Field: Medicine
Funded outputs count: 26
Funder award ID: R01DK089883
OpenAlex ID: G2412647930
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation
2025 · Beste Mutlu, Kfir Sharabi, et al. · Cell chemical biology
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity
2025 · Pedro Latorre-Muro, Tevis Vitale, et al. · Nature Cell Biology · 4
PDF
Structural basis of respiratory complex adaptation to cold temperatures
2024 · Young-Cheul Shin, Pedro Latorre-Muro, et al. · Cell · 19
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation
2024 · Beste Mutlu, Kfir Sharabi, et al. · Cell chemical biology · 7
Structural basis of respiratory complexes adaptation to cold temperatures
2024 · Young-Cheul Shin, Pedro Latorre-Muro, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
PDF
A sweet way to regulate cellular growth: OGT and mTOR join forces
2023 · Pedro Latorre-Muro, Pere Puigserver · Molecular Cell · 5
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism
2023 · Jee Hyung Sohn, Beste Mutlu, et al. · Cell Metabolism · 38
Mechanisms of mitochondrial respiratory adaptation
2022 · Christopher F. Bennett, Pedro Latorre-Muro, et al. · Nature Reviews Molecular Cell Biology · 310
Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease
2021 · Beste Mutlu, Pere Puigserver · Journal of Clinical Investigation · 2
PDF
Targeting adaptive cellular responses to mitochondrial bioenergetic deficiencies in human disease
2021 · Christopher F. Bennett, Conor T. Ronayne, et al. · FEBS Journal · 12
PDF
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly
2021 · Christopher F. Bennett, Katherine E. O’Malley, et al. · Nature Chemical Biology · 50
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation
2021 · Pedro Latorre-Muro, Katherine E. O’Malley, et al. · Cell Metabolism · 111
PDF
Tetracyclines promote survival and fitness in mitochondrial disease models
2021 · Elizabeth A. Perry, Christopher F. Bennett, et al. · Nature Metabolism · 60
PDF
Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic action
2020 · Clint D. J. Tavares, Stefan Aigner, et al. · Proceedings of the National Academy of Sciences · 32
PDF
GCN5 acetyltransferase in cellular energetic and metabolic processes
2020 · Beste Mutlu, Pere Puigserver · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · 74
Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
2020 · Chi Luo, Jiaxin Liang, et al. · Cancer Research · 20
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
2020 · Eduardo Balsa, Elizabeth A. Perry, et al. · Nature Communications · 142
PDF
Autophagy mediates hepatic GRK2 degradation to facilitate glucagon‐induced metabolic adaptation to fasting
2019 · Marta Cruces‐Sande, Alba C. Arcones, et al. · The FASEB Journal · 14
Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives
2019 · Kfir Sharabi, Clint D. J. Tavares, et al. · Current Diabetes Reports · 18
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis
2019 · Eduardo Balsa, Meghan S. Soustek, et al. · Molecular Cell · 325
PDF
Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting
2017 · Maximilian Hatting, Amy K. Rines, et al. · Cell Metabolism · 54
PDF
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
2016 · Amy K. Rines, Kfir Sharabi, et al. · Nature Reviews Drug Discovery · 376
Molecular pathophysiology of hepatic glucose production
2015 · Kfir Sharabi, Clint D.J. Tavares, et al. · Molecular Aspects of Medicine · 325
USP7 Attenuates Hepatic Gluconeogenesis Through Modulation of FoxO1 Gene Promoter Occupancy
2014 · Jessica A. Hall, Mitsuhisa Tabata, et al. · Molecular Endocrinology · 45
PDF
Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex
2014 · Mitsuhisa Tabata, Joseph T. Rodgers, et al. · Diabetes · 34
Year
Topic